RT Journal Article
T1 Time trends incidence of celiac disease in a Spanish population
A1 Cabo del Riego, Julia María
A1 Núñez Iglesias, María Jesús
A1 Blanco Hortas, Andrés
A1 Álvarez Fernández, Tamara
A1 Corchero, Ignacio
A1 Novío Mallón, Silvia
A1 Paz Carreira, José
A1 García-Plata González, Carmen
A1 González-Ramirez, José Abel
A1 Zaera, Sofía
A1 Freire-Garabal Núñez, Manuel
K1 Adult
K1 Celiac disease
K1 Child
K1 Diagnosis
K1 Elderly
K1 Incidence
AB Background/objective: Very few studies on celiac disease (CD) incidence across all age groups have been carried out so far, particularly in Spain. We evaluate the time trend incidence of CD of children, adults and elderly.Methods: Prospective study. Using an integrative primary and tertiary care setting approach with a standardized algorithm we identify all new cases of CD from January 1, 2012, to December 31, 2019, in a well-defined area of Galicia county, Spain. The crude incidence rate of CD was calculated as new cases per 100.000 person/year. Incidence rates were stablished by age categories 0-4, 5-19, 20-44, 45-64, 65-84, ≥ 85 and periods of 1-year intervals.Results: Between 2012 and 2019, 19,564 patients with suspicion and risk of CD were tested. 294 new cases of CD were diagnosed. Increasing CD incidence was observed from 13.11 per 100.000 person/year in 2012 to 20.92 per 100.000 100.000 person/year in 2019 (95% CI = 6.8-15.5). The temporal trend in incidence rates diverges between different age groups; showing a high incidence with stable pattern in children and young people whereas exhibiting an increasing incidence in adult/elderly, so that the incidence almost triple from 2012 to 2019. Classic CD symptoms decreasing frequency among incident cases was observed over time.Conclusions: A standardized algorithm for CD diagnosis with first-line serology testing followed by biopsy, if needed according to guidelines, confirmed the CD increasing incidence over 8 years period.
PB Public Library of Science
SN 1932-6203
YR 2025
FD 2025-07-11
LK https://hdl.handle.net/10347/43323
UL https://hdl.handle.net/10347/43323
LA eng
NO Cabo del Riego JM, Núñez-Iglesias MJ, Blanco Hortas A, Álvarez Fernández T, Corchero I, Novío S, et al. (2025) Time trends incidence of celiac disease in a Spanish population. PLoS One 20(7): e0326634. https://doi.org/10.1371/journal. pone.0326634
DS Minerva
RD 26 abr 2026