RT Journal Article
T1 Phage–host coevolution in natural populations
A1 Piel, Damien
A1 Barcia-Cruz, Rubén
A1 Dubert Pérez, Javier
A1 Le Roux, Frédérique
AB Coevolution between bacteriophages (phages) and their bacterial hosts occurs through changes in resistance and counter-resistance mechanisms. To assess phage–host evolution in wild populations, we isolated 195 Vibrio crassostreae strains and 243 vibriophages during a 5-month time series from an oyster farm and combined these isolates with existing V. crassostreae and phage isolates. Cross-infection studies of 81,926 host–phage pairs delineated a modular network where phages are best at infecting co-occurring hosts, indicating local adaptation. Successful propagation of phage is restricted by the ability to adsorb to closely related bacteria and further constrained by strain-specific defence systems. These defences are highly diverse and predominantly located on mobile genetic elements, and multiple defences are active within a single genome. We further show that epigenetic and genomic modifications enable phage to adapt to bacterial defences and alter host range. Our findings reveal that the evolution of bacterial defences and phage counter-defences is underpinned by frequent genetic exchanges with, and between, mobile genetic elements.
PB Nature Research
SN 2058-5276
YR 2022
FD 2022-07-01
LK https://hdl.handle.net/10347/38824
UL https://hdl.handle.net/10347/38824
LA eng
NO Piel, D., Bruto, M., Labreuche, Y. et al. Phage–host coevolution in natural populations. Nat Microbiol 7, 1075–1086 (2022). https://doi.org/10.1038/s41564-022-01157-1
DS Minerva
RD 23 abr 2026