RT Journal Article
T1 Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage
A1 Rodríguez Villar, Jéssica
A1 Pérez González, Cibrán
A1 Martínez-Calvo, Miguel
A1 Mosquera Mosquera, Jesús
A1 Mascareñas Cid, José Luis
AB Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions of bZIP transcription factors. While the dimer binds designed DNA sequences with good affinities, the peptide–DNA complex can be readily dismounted by addition of palladium reagents that trigger the cleavage of the spacer, and the release of unfunctional monomeric peptides
PB Royal Society of Chemistry
YR 2022
FD 2022
LK http://hdl.handle.net/10347/27429
UL http://hdl.handle.net/10347/27429
LA eng
NO RSC Adv., 2022, 12, 3500
NO We are thankful for the financial support from the Xunta de Galicia (Centro singular de investigación de Galicia acreditación 2019–2022, ED431G 2019/03) and the European Union (European Regional Development Fund – ERDF). We also thank support given by the Spanish grants PID2019-108624RB-I00, the Xunta de Galicia (grants 2015-CP082, ED431C 2017/19 and 2021-CP054, ED431C-2021/25) and the European Research Council (Advanced Grant No. 340055). MMC and JR thank the MCIN/AEI for their Postdoctoral fellowships (IJCI-2014-19326 and IJC2019-040358-I)
DS Minerva
RD 29 abr 2026