RT Journal Article
T1 Serotonin involvement in okadaic acid-induced diarrhoea in vivo
A1 Louzao Ojeda, María del Carmen
A1 Costas Sánchez, Celia
A1 Abal Camaño, Paula
A1 Suzuki, Toshiyuki
A1 Watanabe, Ryuichi
A1 Vilariño del Río, Natalia
A1 Carrera González, María Cristina
A1 Boente Juncal, Andrea
A1 Vale González, María del Carmen
A1 Rodríguez Vieytes, Mercedes
A1 Botana López, Luis Miguel
K1 Okadaic acid
K1 Diarrhoeic shellfish poisoning (DSP)
K1 5-Hydroxytryptamine
K1 Neuropeptide Y
K1 Peptide YY
AB The consumption of contaminated shellfish with okadaic acid (OA) group of toxins leads to diarrhoeic shellfish poisoning (DSP) characterized by a set of symptoms including nausea, vomiting and diarrhoea. These phycotoxins are Ser/Thr phosphatase inhibitors, which produce hyperphosphorylation in cellular proteins. However, this inhibition does not fully explain the symptomatology reported and other targets could be relevant to the toxicity. Previous studies have indicated a feasible involvement of the nervous system. We performed a set of in vivo approaches to elucidate whether neuropeptide Y (NPY), Peptide YY (PYY) or serotonin (5-HT) was implicated in the early OA-induced diarrhoea. Fasted Swiss female mice were administered NPY, PYY(3–36) or cyproheptadine intraperitoneal prior to oral OA treatment (250 µg/kg). A non-significant delay in diarrhoea onset was observed for NPY (107 µg/kg) and PYY(3–36) (1 mg/kg) pre-treatment. On the contrary, the serotonin antagonist cyproheptadine was able to block (10 mg/kg) or delay (0.1 and 1 mg/kg) diarrhoea onset suggesting a role of 5-HT. This is the first report of the possible involvement of serotonin in OA-induced poisoning
PB Springer
SN 0340-5761
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26635
UL http://hdl.handle.net/10347/26635
LA eng
NO Louzao, M.C., Costas, C., Abal, P. et al. Serotonin involvement in okadaic acid-induced diarrhoea in vivo. Arch Toxicol 95, 2797–2813 (2021). https://doi.org/10.1007/s00204-021-03095-z
NO This work was supported by Ministerio de Economía, Industria y Competitividad AEI/FEDER, UE (AGL2016-78728-R), (IISCIII/PI19/001248); Conselleria de Cultura, Educacion e Ordenación Universitaria, Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01); European Union Interreg AlertoxNet (EAPA-317-2016), Interreg Agritox (EAPA-998-2018), and H2020 778069-EMERTOX. Celia Costas and Andrea Boente-Juncal are recipient of a scholarship from Ministerio de Ciencia, Innovación y Universidades Grant FPU18/05681 and FPU16/07129, respectively
DS Minerva
RD 24 abr 2026