RT Journal Article
T1 Comprehensive characterization of volatile and semi-volatile compounds in e-liquids for electronic cigarette using gas chromatography accurate mass spectrometry
A1 Cobo Golpe, María
A1 Ramil Criado, María
A1 Rodríguez Pereiro, Isaac
K1 E-liquids
K1 Non-target screening
K1 Gas chromatography
K1 Time-of-flight mass spectrometry
AB The consumption of electronic cigarettes is a habit with an increasing prevalence, particularly among youths. Knowing the composition of e-liquids used in these devices represents the first step to understand the potential impact of e-smoking in the health of consumers. Herein, a non-target screening methodology was applied to the identification of volatile and semi-volatile compounds in a set of e-liquids from different suppliers, with different flavors, and containing different kinds of additives, such as nicotine or cannabidiol. To this end, samples were characterized by gas chromatography accurate mass spectrometry, using a time-of-flight mass analyzer. Combination of deconvoluted electronic ionization mass spectra with linear retention index values, obtained for two columns with different selectivity, permitted the identification of more than 250 chemicals with different confidence levels. Among them, respiratory pro-inflammatory compounds, acetals of propylene glycol and glycerin with aldehydes, nicotine-related and non-related alkaloids, and psychoactive cannabinoids were confirmed as concerning compounds in e-liquid samples. Concentration ratios between propylene glycol acetals and parent aldehydes varied in the range from 2% (ethyl vanillin) to more than 80% (case of benzaldehyde). The ratios between the concentrations of delta-9-tetrahydrocannabinol and cannabidiol in e-liquids stayed in the range from 0.02% to 0.3%
PB Elsevier
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30748
UL http://hdl.handle.net/10347/30748
LA eng
NO Journal of Chromatography A 1703 (2023) 464114
NO M.C.G. thanks a FPI pre-doctoral grant to the Spanish Ministry of Science & Innovation. This study was supported by Spanish Government and Xunta de Galicia through grants PGC2018–094613-B-I00 and ED431C 2021/06, respectively. Both projects are co-funded by the EU FEDER program
DS Minerva
RD 22 abr 2026