RT Journal Article
T1 Not so rigid capsids based on cyclodextrin complexes: keys to design
A1 Suárez Lestón, Fabián
A1 Fernández Garrido, Pablo
A1 Piñeiro Guillén, Ángel
A1 García Fandiño, Rebeca
K1 Cyclodextrins
K1 Membranes
K1 Monolayers
K1 Molecular dynamics simulations
K1 Self-assembly
K1 Bilayers
AB Membranes based on cyclodextrin complexes can be used as functional nanocarrier envelopers by chemical modifications of the cyclodextrin hydroxyl groups or by encapsulating different ligands in their cavities. Experiments: Molecular dynamics simulations of monolayers and bilayers based on supramolecular complexes consisting of two α or β-cyclodextrin and one sodium dodecylsulfate or dodecane at 283 K and at 298 K were performed. Findings: It is shown that the structure and main interactions stabilizing the membranes, as well as their permeability to water and ions can be tuned by changing the cyclodextrin, the ligand, the number of layers or/and the temperature. These results provide new evidences about both their dynamic nature and the interactions responsible for the stabilization of the membranes and will facilitate the design of new functional capsides and applications based on cyclodextrin complexes
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29092
UL http://hdl.handle.net/10347/29092
LA eng
NO Journal of Colloid and Interface Science  623 (2022) 938-946
NO This work has received financial support from the Spanish Agencia Estatal de Investigación (AEI) and the European Regional Development Fund - ERDF (PID2019-111126RB-100, RTI2018-098795-A-I00, and PID2019-111327GB-I00) and by the Xunta de Galicia (ED431F 2020/05 and Centro singular de investigación de Galicia accreditation 2019-2022, ED431G 2019/03) and the European Union (ERDF). R.G.-F. thanks Ministerio de Ciencia, Innovación y Universidades for a “Ramón y Cajal” contract (RYC-2016-20335). P. F. G. thanks the Spanish Ministry of Economy and Competitiveness and the European Social Fund for his predoctoral research grant, reference BES-2016-076761.
DS Minerva
RD 23 abr 2026