RT Journal Article
T1 Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep
A1 Hamad Minervino, Antonio Humberto
A1 López Alonso, María Marta
A1 Barrêto Júnior, Raimundo Alves
A1 Rodrigues, Frederico Augusto Mazzocca Lopes
A1 Araújo, Carolina Akiko Sato Cabral de
A1 Sousa, Rejane Santos
A1 Mori, Clara Satsuki
A1 Miranda Castañón, Marta Inés
A1 Oliveira, Francisco Leonardo Costa
A1 Antonelli, Alexandre Coutinho
A1 Lippi Ortolani, Enrico
K1 Chronic copper poisoning
K1 Toxicity
K1 Sheep
K1 Liver
K1 Metallothionein
AB The aim of this study was to evaluate whether zinc (Zn) supplementation protects against hepatic copper (Cu) accumulation in copper-loaded sheep. Forty cross-bred lambs were assigned to five experimental groups. These included the control group (C) and four treatment groups that received Cu and/or Zn supplementation (dry matter (DM) basis) over 14 weeks, as follows: Cu (450 mg Cu/kg); Zn-35 (450 mg Cu + 35 mg Zn/kg); Zn-150 (450 mg Cu + 150 mg Zn/kg); and Zn-300 (450 mg Cu + 300 mg Zn/kg). Blood, liver, and bile samples were obtained for mineral determination by inductively coupled plasma optical emission spectrometry (ICP–OES). The hepatic metallothionein (MT) concentrations were also determined. At the end of the experiment, hepatic Cu concentrations were higher in all Cu-supplemented groups than in C. Hepatic Cu accumulation was lower in the groups receiving the Zn supplementation than in the Cu group, although the difference was only statistically significant (66%) in the Zn-300 group. The MT concentrations tended to be higher (almost two-fold) in the Zn groups (but were not dose related) than in the C and Cu groups, and they were related to hepatic Zn concentrations. Zn supplementation at 300 mg/kg DM is useful for preventing excessive hepatic Cu accumulation in sheep exposed to high dietary concentrations of Cu
PB MDPI
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22140
UL http://hdl.handle.net/10347/22140
LA eng
NO Minervino, A.H.H.; López-Alonso, M.; Barrêto Júnior, R.A.; Rodrigues, F.A.M.L.; Araújo, C.A.S.C.; Sousa, R.S.; Mori, C.S.; Miranda, M.; Oliveira, F.L.C.; Antonelli, A.C.; Ortolani, E.L. Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep. Animals 2018, 8, 227
NO This research was funded by the São Paulo Research Foundation (FAPESP). A research productivity fellowship was granted by the National Council for Scientific and Technological Development (CNPq) to AHHM
DS Minerva
RD 22 abr 2026