RT Journal Article
T1 A novel genomic island encodes vibrioferrin synthesis in the marine pathogen Photobacterium damselae subsp. damselae
A1 Puentes Corral, Beatriz
A1 Souto Rodríguez, Alba
A1 Balado Dacosta, Miguel
A1 Rodríguez, Jaime
A1 Rodríguez Osorio, Carlos
A1 Jiménez González, Carlos
A1 Lemos Ramos, Manuel Luis
K1 Photobacterium damselae subsp. damselae
K1 Siderophores
K1 Vibrioferrin
K1 Genomic islands
K1 Virulence
AB In this study, we identified and analyzed a novel genomic island (GI), named pddGI-1, located on chromosome II of certain strains of the marine pathogen Photobacterium damselae subsp. damselae (Pdd). This GI shares structural similarities with other GIs found in Vibrio species, such as the Vibrio seventh pandemic island-II (VSP-II) of V. cholerae. The pddGI-1 island is a mosaic of gene blocks that encode functions related to ROS defense, anaerobic energy metabolism, and restriction-modification (RM) systems. Notably, pddGI-1 also includes a complete vibrioferrin siderophore system, enabling the bacteria to thrive in low-iron environments. Vibrioferrin was chemically identified from cell-free supernatants of Pdd RG91. Additionally, a pvsD mutant deficient in vibrioferrin biosynthesis was generated and analyzed. The results suggest that Pdd strains harbouring pddGI-1 gain a distinct growth advantage under iron-limited conditions. These findings, along with previous research, highlight the significant heterogeneity in iron assimilation systems among Pdd strains.
PB Elsevier
SN 0882-4010
YR 2025
FD 2025-02-01
LK https://hdl.handle.net/10347/42833
UL https://hdl.handle.net/10347/42833
LA eng
NO Puentes, B., Souto, A., Balado, M., Rodríguez, J., Osorio, C. R., Jiménez, C. & Lemos, M. L. (2025). Microbial Pathogenesis 199 107218 https://doi.org/10.1016/j.micpath.2024.107218
NO The work was supported by grants PID2021-122732OB-C21/C22 and PID2022-141987OB-I00 from MCIN/AEI/10.13039/ 501100011033/FEDER “A way to make Europe” (AEI, Spanish State Agency for Research and FEDER Programme from the European Union). M.B. was supported by grant PID2019-103891RJ-I00 from MCIN/AEI/ 10.13039/501100011033 (Spain). Work at the University of Santiago de Compostela and University of A Coruna ˜ was also supported by grants ED431C 2022/023 and ED431C 2022/39, respectively, from Xunta de Galicia, Spain.
DS Minerva
RD 23 abr 2026