RT Journal Article
T1 Increased levels of syndecan-3 are associated with childhood obesity
A1 Muñoz Moreno, Diego
A1 Prida, Eva
A1 Baumann Aldaz, Axel Yain
A1 Pérez Lois, Raquel
A1 Bascoy Otero, Miguel
A1 Díaz-Garzón Dopico, Laura
A1 Brea García, Beatriz
A1 Villalón Vázquez, María
A1 Picáns Leis, Rosaura
A1 Vázquez Cobela, Rocío
A1 Estany Gestal, Ana
A1 Seoane Camino, Luisa María
A1 Leis Trabazo, María Rosaura
A1 Al-Massadi, Omar
A1 Quiñones, Mar
K1 Human metabolism
K1 Pediatrics
AB Childhood obesity is considered an important risk factor for developing obesity in adult. Syndecan-3 (SDC3) has recently come into focus as a possible molecular target involved in alterations of energy homeostasis, however, its role in childhood obesity remains undefined. We measured mRNA expression levels of SDC3 in children and adolescents with obesity from peripheral blood mononuclear cells and correlating them with different anthropometric and biochemical parameters. We performed a cross-sectional study involving 143 Caucasian children and adolescents. We found increased SDC3 expression in children and adolescents with obesity. In addition, a positive statistical correlation has been found between the levels of SDC3 with body weight, BMI, BMI Z score, fat mass, waist circumference, insulin levels, HOMA-IR index, and maximum blood pressure. Finally, a multiple linear regression analysis indicated that the BMI Z score variable was the most significant. Taken together, our results highlight a still unexplored link between SDC3 and childhood obesity
PB CellPress
YR 2025
FD 2025-08-15
LK https://hdl.handle.net/10347/45137
UL https://hdl.handle.net/10347/45137
LA eng
NO Muñoz-Moreno, D., Prida, E., Baumann, A. Y., Pérez-Lois, R., Bascoy, M., Dopico, L. D., Brea-García, B., Villalón, M., Picans-Leis, R., Vázquez-Cobela, R., Estany-Gestal, A., Seoane, L. M., Leis, R., Al-Massadi, O., & Quiñones, M. (2025). Increased levels of syndecan-3 are associated with childhood obesity. iScience, 28(8), 113111. https://doi.org/10.1016/j.isci.2025.113111
NO This study has been funded by Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación and co-funded by the FEDER Program of European Union (FEDER) (M.Q.: PID2022-142084OA-100). Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union (R.L.: PI20/00924; L.M.S.: PI22/00202 and O.A.-M.: PI21/01216 and PI24/00916). GAIN-XUNTA Galicia Proyectos de Excelencia (M.Q.: IN607D 2023/02; O.A.-M.: IN607D-2022-07; L.M.S.: IN607D-2022-04). Fundación de la Sociedad Gallega de Endocrinología y Nutrición (M.Q.:2023) and (O.A.-M.:2022). Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the ISCIII of Spain, which is supported by FEDER funds. D.M.-M., E.P., and R.P.-Lois hold a IDIS fellowship. M.B. is a recipient of a predoctoral contract PFIS funded by the ISCIII (FI23/00256). M.Q. and O.A.-M. were funded by a research contract Miguel Servet (CP21/00108 and CP20/00146, respectively) from the ISCIII
DS Minerva
RD 29 abr 2026