RT Journal Article
T1 Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake
A1 Liñares Pose, Laura
A1 Rial Pensado, Eva
A1 Estévez Salguero, Ánxela
A1 Milbank, Edward
A1 González García, Ismael
A1 Rodríguez, Claudia
A1 Seoane Collazo, Patricia
A1 Martínez Sánchez, Noelia
A1 Nogueiras Pozo, Rubén
A1 Prieto, Dolores
A1 Diéguez González, Carlos
A1 Contreras, Cristina
A1 López Pérez, Miguel A.
K1 Brown adipose tissue
K1 Browning
K1 ER stress
K1 GRP78
K1 Hypothalamus
K1 Thermogenesis
K1 White adipose tissuestress
K1 GRP78
K1 Hypothalamus
K1 Thermogenesis
K1 White adipose tissue
AB Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein kinase (AMPK). Herein, we aimed to investigate whether genetic over-expression of GRP78 in the ventromedial nucleus of the hypothalamus (VMH: a key site regulating thermogenesis) could ameliorate very high fat diet (vHFD)-induced obesity. Our data showed that stereotaxic treatment with adenoviruses harboring GRP78 in the VMH reduced hypothalamic endoplasmic reticulum ER stress and reversed vHFD-induced obesity. Herein, we also demonstrated that this body weight decrease was more likely associated with an increased BAT thermogenesis and browning of white adipose tissue (WAT) than to anorexia. Overall, these results indicate that the modulation of GRP78 in the VMH may be a target against obesity
PB MDPI
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22089
UL http://hdl.handle.net/10347/22089
LA eng
NO Liñares-Pose, L.; Rial-Pensado, E.; Estévez-Salguero, Á.; Milbank, E.; González-García, I.; Rodríguez, C.; Seoane-Collazo, P.; Martinez-Sánchez, N.; Nogueiras, R.; Prieto, D.; Diéguez, C.; Contreras, C.; López, M. Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake. Genes 2018, 9, 357
NO The research leading to these results has received funding from Xunta de Galicia (R.N.: 2015-CP080 and 2016-PG057; M.L.: 2015-CP079), MINECO co-funded by the FEDER Program of EU (R.N.: BFU2015-70664R; D.P.: SAF2016-77526-R; C.D.: BFU2017-87721; M.L.: SAF2015-71026-R and BFU2015-70454-REDT/Adipoplast). The CiMUS is supported by the Xunta de Galicia (2016-2019, ED431G/05). L.L.-P. is a recipient of a fellowship from Xunta de Galicia (ED481A-2016/094); E.R.-P. is a recipient of a fellowship from MINECO (BES-2015-072743); A.E.-S. is a recipient of a fellowship from MINECO (FPI/BES-2016-077439); C.R. is a recipient of a fellowship from MINECO (FPU16/04582). CIBER Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII
DS Minerva
RD 24 abr 2026