RT Journal Article
T1 Novel Phthalazin-1(2H)-One derivatives displaying a dithiocarbamate moiety as potential anticancer agents
A1 Vila, Noemí
A1 Besada Pereira, Pedro
A1 Brea Floriani, José Manuel
A1 Loza García, María Isabel
A1 Terán Moldes, Carmen
K1 Phthalazinone
K1 Dithiocarbamate
K1 Hybridization
K1 One-pot synthesis
K1 Antiproliferative activity
K1 Drug-likeness
K1 Toxicity
AB Nowadays, cancer disease seems to be the second most common cause of death worldwide. Molecular hybridization is a drug design strategy that has provided promising results against multifactorial diseases, including cancer. In this work, two series of phthalazinone-dithiocarbamate hybrids were described, compounds 6–8, which display the dithiocarbamate scaffold at N2, and compounds 9, in which this moiety was placed at C4. The proposed compounds were successfully synthesized via the corresponding aminoalkyl phthalazinone derivatives and using a one-pot reaction with carbon disulfide, anhydrous H3PO4, and different benzyl or propargyl bromides. The antiproliferative effects of the titled compounds were explored against three human cancer cell lines (A2780, NCI-H460, and MCF-7). The preliminary results revealed significant differences in activity and selectivity depending on the dithiocarbamate moiety location. Thus, in general terms, compounds 6–8 displayed better activity against the A-2780 and MCF-7 cell lines, while most of the analogues of the 9 group were selective toward the NCI-H460 cell line. Compounds 6e, 8e, 6g, 9a–b, 9d, and 9g with IC50 values less than 10 µM were the most promising. The drug-likeness and toxicity properties of the novel phthalazinone-dithiocarbamate hybrids were predicted using Swiss-ADME and ProTox web servers, respectively
PB MDPI
YR 2022
FD 2022-11-22
LK https://hdl.handle.net/10347/45252
UL https://hdl.handle.net/10347/45252
LA eng
NO Vila, N., Besada, P., Brea, J., Loza, M. I., & Terán, C. (2022). Novel Phthalazin-1(2H)-One Derivatives Displaying a Dithiocarbamate Moiety as Potential Anticancer Agents. Molecules, 27(23), 8115. https://doi.org/10.3390/molecules27238115
NO This research was supported with funding from Universidade de Vigo, Xunta de Galicia (ED431C 2022/20 and ED431G 2019/02) and European Regional Development Fund (ERDF)
DS Minerva
RD 28 abr 2026