RT Journal Article
T1 Antibiotic adjuvants – A strategy to unlock bacterial resistance to antibiotics
A1 González Bello, Concepción
K1 Resistance breakers
K1 Antibiotic potentiators
K1 ESKAPE pathogens
K1 b-Lactamase inhibitors
K1 Efflux pump inhibitors
K1 Permeabilizers
AB Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the numberof strains that are resistant to multiple types of antibiotics has increased dramatically each year and hasspread worldwide. To unlock this problem, the use of an ‘antibiotic adjuvant’ in combination with anantibiotic is now being exploited. This approach enables us to prolong the lifespan of these life-savingdrugs. This digests review provides an overview of the main types of antibiotic adjuvants, the basis oftheir operation and the remaining issues to be tackled in this field. Particular emphasis is placed on thosecompounds that are already in clinical development, namely b-lactamase inhibitors
PB Elsevier
SN 0960-894X
YR 2017
FD 2017-08-14
LK http://hdl.handle.net/10347/16122
UL http://hdl.handle.net/10347/16122
LA eng
NO Financial support from the Spanish Ministry of Economy andCompetiveness (SAF2016-75638-R), the Xunta de Galicia (Centrosingular de investigación de Galicia accreditation 2016-2019,ED431G/09) and the European Union (European Regional DevelopmentFund – ERDF) is gratefully acknowledged
DS Minerva
RD 30 abr 2026