RT Journal Article
T1 The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments
A1 Rodríguez Villar, Jéssica
A1 Mosquera Mosquera, Jesús
A1 Rodríguez Couceiro, José
A1 Vázquez Sentís, Marco Eugenio
A1 Mascareñas Cid, José Luis
AB We report the development of chimeric DNA binding peptides comprising a DNA binding fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric zinc finger module) and an AT-Hook peptide motif. The resulting peptide conjugates display high DNA affinity and excellent sequence selectivity. Furthermore, the AT-Hook motif also favors the cell internalization of the conjugates
PB Royal Society of Chemistry
YR 2015
FD 2015
LK http://hdl.handle.net/10347/18337
UL http://hdl.handle.net/10347/18337
LA eng
NO Rodríguez, J., Mosquera, J., Couceiro, J., Vázquez, M., & Mascareñas, J. (2015). The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments. Chemical Science, 6(8), 4767-4771. doi: 10.1039/c5sc01415h
NO We are thankful for the support given by the Spanish grants SAF2013-41943 R, CTQ2012-31341, and CTQ2013-49317-EXP; the Xunta de Galicia GRC2013-041, the ERDF and the European Research Council (Advanced Grant 340055). Support of COST Action CM1105 and the Orfeo-Cinqa also is kindly acknowledged. J.R. thanks the Xunta de Galicia for her PhD fellowship
DS Minerva
RD 23 abr 2026