RT Journal Article
T1 Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
A1 Nebot García, Carolina
A1 Iglesias, A.
A1 Regal López, Patricia
A1 Miranda López, José Manuel
A1 Cepeda Sáez, Alberto
A1 Fente Sampayo, Cristina Asunción
K1 multi-class
K1 residues
K1 coccidiostats
K1 veterinary drugs
K1 milk
K1 LC–MS/MS
K1 657/2002/EC
AB Even if coccidiostats are not generally employed in dairy cows, maximum levels for these substances in milk samples have been set up in Commission Regulation 124/2009. Due to public health concerns regarding the presence of veterinary drug residues in milk, the aim of the present work is to report a multi-class high performance liquid chromatography–tandem mass spectrometry method for the simultaneous extraction, identification and quantification of seven coccidiostats, seven antimicrobial agents, three corticosteroids and an antifungal agent. Validation was conducted following the guidelines established in the European Commission Decision 2002/657/CE at the maximum concentration permitted in milk by the European Union for each drug. The method was successfully applied in 100 raw milk samples collected from ten local dairy farms and 15 milk samples bought in supermarkets. This method could be applied in routine analysis of milk samples by the dairy industry, replacing the current, non-differentiating, screening method.
PB Elsevier
SN 0958-6946
YR 2012
FD 2012-01
LK https://hdl.handle.net/10347/45558
UL https://hdl.handle.net/10347/45558
LA eng
NO Nebot, C., Iglesias, A., Regal, P., Miranda, J., Cepeda, A., & Fente, C. (2012). Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry. International Dairy Journal, 22(1), 78–85. doi:10.1016/j.idairyj.2011.09.001
DS Minerva
RD 25 abr 2026