RT Journal Article
T1 Assessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment
A1 Mallo López, Sabela Carme
A1 Ismail, Zahinoor
A1 Pereiro Rozas, Arturo X.
A1 Facal Mayo, David
A1 Lojo Seoane, Cristina
A1 Campos Magdaleno, María
A1 Juncos Rabadán, Onésimo
K1 Behavioral and psychological symptoms of dementia
K1 Dementia
K1 Mild behavioral impairment
K1 Mild cognitive impairment
K1 Neuropsychiatric symptoms
K1 Preclinical dementia
K1 Prodromal dementia
AB Background:Neuropsychiatric symptoms (NPS) are non-cognitive, behavioral, or psychiatric symptoms, common in mild cognitive impairment (MCI) and associated with a higher risk of dementia. Mild behavioral impairment (MBI) is a validated diagnostic entity, that describes the emergence of later life NPS in pre-dementia states. The Mild Behavioral Impairment Checklist (MBI-C) is the first measure developed to assess MBI.Objective:To estimate the prevalence of MBI in people with MCI and to study the score distribution, sensitivity, specificity, diagnostic utility of the MBI-C, and its correlations with neuropsychological tests.Methods:One hundred eleven MCI participants were evaluated with the Questionnaire for Subjective Memory Complaints (QSMC), Mini-Mental State Examination, Cambridge Cognitive Assessment-Revised, Neuropsychiatric Inventory-Questionnaire (NPI-Q), Geriatric Depression Scale-15 items (GDS-15), Lawton and Brody Index, and the MBI-C, which was administered by phone to participants’ informants. Descriptive, logistic regression, ROC curve, and bivariate correlations analyses were performed.Results:MBI diagnosis prevalence was 14.2%. The total MBI-C score differentiated people with MBI at a cutoff-point of 6.5, optimizing sensitivity and specificity. MBI-C total score correlated positively with NPI-Q, QSMC, GDS-15, and Lawton and Brody Index.Conclusion:The total MBI-C score, obtained by phone administration, is sensitive for detecting MBI in people with MCI. The MBI-C scores indicated that MCI participants had subtle NPS that were correlated to their subjective memory complaints reported by informants, depressive symptoms, and negatively with Instrumental Activities of Daily Living. Further research should be done to clarify the predictive role of NPS in MCI for incident dementia.
PB IOS Press
SN 1387-2877
YR 2018
FD 2018-08-01
LK http://hdl.handle.net/10347/17404
UL http://hdl.handle.net/10347/17404
LA eng
NO Mallo, S., Ismail, Z., Pereiro, A., Facal, D., Lojo-Seoane, C., Campos-Magdaleno, M., & Juncos-Rabadán, O. (2018). Assessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment. Journal Of Alzheimer's Disease, 1-13. doi: 10.3233/jad-180131
NO The study was funded by the Spanish Ministry of Economy and Competitiveness (ref. PSI2014-55316- C3-1-R) and the Galician Autonomous Government Grant (ref. ED431C2017/27). The first author is funded by a fellowship from the Spanish Ministry of Economy and Competitiveness (ref. BES-2015- 071253)
DS Minerva
RD 22 abr 2026