RT Journal Article
T1 Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects
A1 Picos Martínez, Aitor
A1 Seoane Lloves, Nuria
A1 Campos Toimil, Manuel
A1 Viña Castelao, María Dolores
K1 Vascular senescence
K1 Aging
K1 DNA damage
K1 Telomere attrition
K1 SASP
K1 ROS
K1 Vascular pathologies
K1 Therapeutic interventions
AB The aging vasculature is characterized by endothelial dysfunction, arterial stiffness, and increased susceptibility to vascular pathologies. Central to these changes is the process of cellular senescence, where endothelial and vascular smooth muscle cells lose their replicative and functional capacity and adopt a pro-inflammatory secretory phenotype. This review provides an overview of the key mechanisms underlying vascular senescence, including the p53/p21 and p16/Rb pathways, the senescence-associated secretory phenotype (SASP), and oxidative stress, examines its contribution to cardiovascular diseases in older adults, and highlights emerging therapeutic strategies aimed at delaying or reversing these age-related vascular changes. In vascular cells, DNA damage, oxidative stress, and chronic inflammation associated with aging converge to amplify senescence. Clinically, vascular senescence is linked with hypertension, atherosclerosis, and increased overall cardiovascular risk. Several interventions, ranging from senolytics to lifestyle factors, show promise in mitigating these changes; however, long-term studies are needed. Given that vascular senescence is a pivotal driver of cardiovascular pathology in aging, targeting senescent cells or their secretory phenotype may potentially offer new avenues for preventing or attenuating age-related vascular diseases. This review presents an updated and integrative overview of vascular senescence, connecting fundamental cellular mechanisms with their clinical manifestations and highlighting the most promising therapeutic interventions.
PB Springer
SN 1389-5729
YR 2025
FD 2025-05-26
LK https://hdl.handle.net/10347/42521
UL https://hdl.handle.net/10347/42521
LA eng
NO Picos, A., Seoane, N., Campos-Toimil, M. et al. Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects. Biogerontology 26, 118 (2025). https://doi.org/10.1007/s10522-025-10256-5
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research was funded by Ministerio de Ciencia e Innovación (Spain): Grant Number PID2020-119178 GB-I00. Xunta de Galicia: Grants for the consolidation and structuring of competitive research units of the SUG, 2023–2026, Grant No. EDT431C 2023/22—Research group GPC GI-1862. This work was supported by CiMUS as a part of CIGUS network (Grant No. ED431G/2023/02).
DS Minerva
RD 24 abr 2026