RT Journal Article
T1 Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates
A1 Barreiro Magdaleno, Elena
A1 Casas Fernández, José Sergio
A1 Couce, María D.
A1 Sánchez Díaz, Agustín
A1 Seoane Prado, Rafael
A1 Pérez Estévez, Antonio
A1 Sordo Rodríguez, José
K1 Gold(I) complexes
K1 Sulfanylpropenoic acids
K1 2-Cyclopentylidene-2-sulfanylacetic acid
K1 Antimicrobial studies
AB Reaction of NaAuCl4·H2O and thiodiglycol (1:3 molar ratio) with 3-(aryl)-2-sulfanylpropenoic acids, H2 xspa = [x:p = 3-phenyl-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-, o-py = 3-(2-pyridyl)-, Clp = 3-(2-chlorophenyl)-, -o-mp = 3-(2-methoxyphenyl)-, -p-mp = 3-(4-methoxyphenyl)-, -o-hp = 3-(2-hydroxyphenyl)-, -p-hp = 3-(4-hydroxyphenyl)-, diBr-o-hp = 3-(3,5-dibromo-2-hydroxyphenyl)] and 2-cyclopentylidene-2-sulfanylacetic acid (H2cpa) in a 1:1 metal/ligand molar ratio gave compounds of the type [Au(Hxspa)] or [Au(Hcpa)]. These compounds were reacted with diisopropylamine to afford [HQ][Au(xspa)] or [HQ][Au(cpa)] (HQ = diisopropylammonium) and with NaOH to afford Na[Au(xspa)]·H2O and Na[Au(cpa)]·H2O. All of the new compounds were isolated and characterised by IR and 1H and 13C NMR spectroscopy. The antimicrobial activities of the complexes against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Pseudomonas aeruginosa and carbapenem-resistant P. aeruginosa were evaluated and compared to those of the equivalent silver(I) complexes. The comparison shows that the gold compounds generally show better activity than the silver analogues against S. aureus and B. subtilis, but low sensitivity against E. coli, P. aeruginosa and C. albicans, suggesting a different mode of antimicrobial action for equivalent silver and gold compounds
PB Springer
SN 2364-821X
YR 2012
FD 2012
LK http://hdl.handle.net/10347/24338
UL http://hdl.handle.net/10347/24338
LA eng
NO Barreiro, E., Casas, J.S., Couce, M.D. et al. Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates. Gold Bull 45, 23–34 (2012). https://doi.org/10.1007/s13404-011-0040-7
NO We thank the Dirección Xeral de I+D, Xunta de Galicia, Spain, for the financial support (IN845B-2010/121)
DS Minerva
RD 24 abr 2026