RT Journal Article
T1 Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes
A1 Amaral, Sandra P.
A1 Tawara, Ma’un Hasan Haroon
A1 Fernández Villamarín, Marcos
A1 Borrajo, Erea
A1 Martínez Costas, José Manuel
A1 Vidal Figueroa, Anxo
A1 Riguera Vega, Ricardo
A1 Fernández Megía, Eduardo
K1 Dendrimers
K1 Hierarchical transfer
K1 Micelles
K1 Polyion complexes
K1 Vesicles
AB The generation of dendrimers is a powerful tool in the control of the size and biodistribution of polyion complexes (PIC). Using a combinatorial screening of six dendrimers (18–243 terminal groups) and five oppositely charged PEGylated copolymers, a dendrimer‐to‐PIC hierarchical transfer of structural information was revealed with PIC diameters that increased from 80 to 500 nm on decreasing the dendrimer generation. This rise in size, which was also accompanied by a micelle‐to‐vesicle transition, is interpreted according to a cone‐ to rod‐shaped progression in the architecture of the unit PIC (uPIC). This precise size tuning enabled dendritic PICs to act as nanorulers for controlled biodistribution. Overall, a domino‐like control of the size and biological properties of PIC that is not attainable with linear polymers is feasible through dendrimer generation
PB Wiley
SN 1433-7851
YR 2018
FD 2018-04-27
LK http://hdl.handle.net/10347/16968
UL http://hdl.handle.net/10347/16968
LA eng
NO Amaral, S., Tawara, M., Fernandez-Villamarin, M., Borrajo, E., Martínez-Costas, J., & Vidal, A. et al. (2018). Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes. Angew. Chem. Int. Ed., 57(19), 5273-5277. doi: 10.1002/anie.201712244
NO This is the peer reviewed version of the following article: Amaral, S., Tawara, M., Fernandez-Villamarin, M., Borrajo, E., Martínez-Costas, J., & Vidal, A. et al. (2018). Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes. Angew. Chem. Int. Ed., 57(19), 5273-5277, which has been published in final form at https://doi.org/10.1002/anie.201712244. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
NO Ministerio de Economía y Competitividad. Grant Numbers: CTQ2015-69021-R, CTQ2014-61470-EXP, BFU2013-43513-R Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia. Grant Numbers: GRC2014/040, Centro Singular de Investigación de Galicia Accreditation 2016-2019, ED431G/09 European Regional Development Fund
DS Minerva
RD 8 jun 2026