RT Journal Article
T1 Peripheral Functionalization of Dendrimers Regulates Internalization and Intracellular Trafficking in Living Cells
A1 Albertazzi, Lorenzo
A1 Fernández Villamarín, Marcos
A1 Riguera Vega, Ricardo
A1 Fernández Megía, Eduardo
AB GATG (gallic acid-triethylene glycol) dendrimers represent appealing nanostructures for biomedical applications. The incorporation of specific ligands and targeting and imaging agents on their surface has resulted in promising tools in diagnosis and drug delivery. With the aim to further explore the versatility of GATG dendrimers in the biomedical field, in this work we study the effect of peripheral substitution on their uptake and intracellular trafficking in living cells. To this end, peripheral groups with different physicochemical properties and biological relevance have been installed on the surface of GATG dendrimers, and their interactions, uptake efficacy, and specificity for certain cell populations studied by confocal microscopy. Finally, this information was used to design a pH-sensitive drug delivery system for the selective release of cargo molecules inside cells after lysosomal localization. These results along with the easy functionalization and modular architecture of GATG dendrimers reveal these systems as promising nanotools in biomedicine
PB American Chemical Society
SN 1043-1802
YR 2012
FD 2012-04-07
LK http://hdl.handle.net/10347/16949
UL http://hdl.handle.net/10347/16949
LA eng
NO Albertazzi, L., Fernandez-Villamarin, M., Riguera, R., & Fernandez-Megia, E. (2012). Peripheral Functionalization of Dendrimers Regulates Internalization and Intracellular Trafficking in Living Cells. Bioconjugate Chemistry, 23(5), 1059-1068. doi: 10.1021/bc300079h
NO This work was financially supported by the Spanish MICINN (CTQ2009-10963 and CTQ2009-14146-C02-02) and the Xunta de Galicia (10CSA209021PR and CN2011/037). M.F.-V. thanks the Spanish Ministry of Education for a FPU fellowship
DS Minerva
RD 4 may 2026