RT Journal Article
T1 Bioactive polymeric scaffolds: multivalent functionalization by Thermal Azide–Alkyne Cycloaddition with Alkynyl Dicarbamates
A1 Tawara, Maun H.
A1 Correa Chinea, Juan Francisco
A1 Leire, Emma
A1 Delgado González, Bruno
A1 Parcero Bouzas, Samuel
A1 Liko, Flonja
A1 Fernández Megía, Eduardo
K1 Dendrons
K1 Fluorescence
K1 Functionalization
K1 Hydrocarbons
K1 Micelles
AB Multivalency enables interactions with higher affinities and specificities than monovalent interactions. The strategy exploited by nature to modulate biorecognition has inspired the design of multivalent conjugates with therapeutic properties. However, chemical functionalization often requires coupling agents, additives, or metal catalysts that complicate isolation and purification. Herein, azide–alkyne cycloaddition (AAC) with alkynyl dicarbamates (Alk-R) is presented as a flexible, reliable, atom-economical, and user-friendly strategy for the multivalent functionalization of polymeric scaffolds. Alk-R functionalized with biologically relevant ligands have been prepared and used for the multivalent AAC functionalization of azide-bearing dendrimers and block copolymers. The resulting polymers with double multivalency reveal a platform for the development of bioinspired functional systems with promising applications in drug delivery: block copolymer micelles and multifunctional nanocarriers with synergistically integrated probes-ligands-drugs. The extension of this strategy to other ligands and scaffolds is expected to open up a wide range of therapeutic and diagnostic opportunities.
PB American Chemical Society
SN 1525-7797
YR 2025
FD 2025
LK https://hdl.handle.net/10347/43316
UL https://hdl.handle.net/10347/43316
LA eng
NO Tawara, M. H., Correa, J., Leire, E., Gonzalez, B. D., Parcero-Bouzas, S., Liko, F., & Fernandez-Megia, E. (2025). Bioactive Polymeric Scaffolds: Multivalent Functionalization by Thermal Azide–Alkyne Cycloaddition with Alkynyl Dicarbamates. "Biomacromolecules". https://doi.org/10.1021/acs.biomac.5c00038
NO This work was supported by grant PID2021-127684OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by ERDF “A way of making Europe.” The authors thank the f inancial support from Xunta de Galicia (ED431C 2022/21, and Centro de Investigación do Sistema Universitario de Galicia accreditation 2023-2027, ED431G 2023/03) and the European Union (European Regional Development Fund� ERDF). B.D.G. thanks Xunta de Galicia for a predoctoral grant. E.L. and F.L. thank the European Commission, Education, Audiovisual and Cultural Executive Agency (EACEA) for an Erasmus Mundus grant under the NanoFar Joint Doctoral Program
DS Minerva
RD 3 may 2026