RT Journal Article T1 Valorisation of pork by-products to obtain antioxidant and antihypertensive peptides A1 López-Pedrouso, María A1 Lorenzo Rodríguez, José Manuel A1 Bou Novensà, Ricard A1 Vázquez Álvarez, José Antonio A1 Valcárcel, Jesús A1 Toldrà Alegret, Mónica A1 Franco Ruiz, Daniel K1 Meat by-products K1 Porcine liver K1 Autolysis K1 Proteolysis K1 Bioactive peptides K1 Peptidomic K1 Endogenous enzymes (proteases) AB The porcine liver could be used for the extraction of zinc-protoporphyrin (ZnPP) as a natural red meat pigment. During the autolysis process, porcine liver homogenates was incubated at pH 4.8 and 45 °C under anaerobic conditions to obtain insoluble ZnPP. After incubation, the homogenates were readjusted at pH 4.8, and at pH 7.5 before being centrifuged at 5500 × g for 20 min at 4 °C and the resulting supernatant were compared with the obtained at pH 4.8 at the beginning of the incubation. The molecular weight distributions of the porcine liver fractions at both pHs were very similar, however, eight essential amino acids were more abundant in fractions obtained at pH 4.8. Regarding the ORAC assay, porcine liver protein fraction at pH 4.8 showed the highest antioxidant capacity but antihypertensive inhibition was similar for both pHs. Peptides with strong bioactivity potential from aldehyde dehydrogenase, lactoylglutathione lyase, SEC14-like protein 3 and others were identified. The findings have demonstrated the potential of the porcine liver to extract natural pigments and bioactive peptides PB Elsevier YR 2023 FD 2023 LK http://hdl.handle.net/10347/30670 UL http://hdl.handle.net/10347/30670 LA eng NO Food Chemistry 423 (2023) 136351 NO Daniel Franco and José M. Lorenzo belong to the competitive reference research group, FunMeat (Axencia Galega de Innovación, GAININ607A2019/01) and Daniel Franco and Jose M. Lorenzo are members of the HealthyMeat network, funded by CYTED (Ref.119RT0568). José Antonio Vázquez and Jesus Valcarcel want to thank the financial support of Xunta de Galicia (Grupos de Potencial Crecimiento, IN607B 2021/11) DS Minerva RD 22 abr 2026