RT Journal Article
T1 Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation
A1 Klajnert, Barbara
A1 Wasiak, Tomasz
A1 Ionov, Maksim
A1 Fernández Villamarín, Marcos
A1 Sousa Hervés, Ana
A1 Correa, Juan
A1 Riguera Vega, Ricardo
A1 Fernández Megía, Eduardo
K1 Dendrimer
K1 Alzheimer's disease
K1 Aβ 1-28
K1 Amyloid peptide
AB The influence of a GATG (gallic acid-triethylene glycol) dendrimer decorated with 27 terminal morpholine groups ([G3]-Mor) on the aggregation process of Alzheimer's peptide has been investigated. Amyloid fibrils were formed from the Aβ 1-28 peptide and the process was monitored by a ThT assay, changes in CD spectra, and transmission electron microscopy. In the presence of [G3]-Mor, more fibrils were built and the process significantly accelerated compared with a control. The cytotoxicity of (1) Aβ and (2) the system [G3]-Mor/Aβ was monitored at different stages of the aggregation process. Prefibrillar species were more toxic than mature fibrils. [G3]-Mor significantly reduced the toxicity of Aβ, probably because of lowering the amount of prefibrillar forms in the system by speeding up the process of fibril formation
PB Elsevier
SN 1549-9634
YR 2012
FD 2012-11
LK http://hdl.handle.net/10347/16971
UL http://hdl.handle.net/10347/16971
LA eng
NO Klajnert, B., Wasiak, T., Ionov, M., Fernandez-Villamarin, M., Sousa-Herves, A., & Correa, J. et al. (2012). Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation. Nanomedicine: Nanotechnology, Biology And Medicine, 8(8), 1372-1378. doi: 10.1016/j.nano.2012.03.005
NO This work was funded by the project “Biological Properties and Biomedical Applications of Dendrimers” operated within Foundation for Polish Science TEAM programme, cofinanced by the European Regional Development Fund.Financial support is also acknowledged from the Spanish MICINN (CTQ2009-10963 and CTQ2009-14146-C02-02) and the Xunta de Galicia (10CSA209021PR and CN2011/037).M.F-V. thanks the Spanish Ministry of Education for a FPU fellowship. The research was performed within the frame of the COST Action TD0802 “Dendrimers for biomedical applications.”
DS Minerva
RD 24 abr 2026