RT Journal Article
T1 Effect of Parenteral Antioxidant Supplementation During the Dry Period on Postpartum Glucose Tolerance in Dairy Cows
A1 Abuelo Sebio, Ángel
A1 Alves-Nores, V.
A1 Hernández Bermúdez, Joaquín
A1 Muiño Otero, Rodrigo
A1 Benedito Castellote, José Luis
A1 Castillo Rodríguez, Cristina
K1 Inflammation
K1 Insulin resistance
K1 Oxidative stress
K1 Transition period
K1 Vitamin E
AB BackgroundExacerbated postparturient insulin resistance (IR) has been associated with several pathologic conditions in dairy cattle. Oxidative stress (OS) plays a causative role in IR in humans, and an association, but not direct relationship, between OS and IR recently has been reported in transition dairy cattle.HypothesisSupplementation with antioxidants shortly before calving improves glucose tolerance after parturition in dairy cattle.AnimalsTen late-pregnant Holstein cows entering their 2nd to 5th lactation.MethodsRandomized placebo-controlled trial: 15 ± 2 days before expected calving, the treatment group received an injection of DL-alpha-tocopheryl acetate at a dosage of 6 mg/kg body weight (BW) and 0.06 mg/kg BW of sodium selenite, and the control group was injected with isotonic saline. During the first week after calving, both groups underwent glucose tolerance testing (0.25 g glucose/kg BW). Commercial assays were used to quantify the concentrations of glucose, insulin, nonesterified fatty acids (NEFA), beta-hydroxybutyrate, and markers of redox status in blood. Data were analyzed using the Mann–Whitney U-test (α = 0.05).ResultsSupplemented cows showed a lower risk for OS, as reflected by a lower OS index (P = .036), different areas under the curve for the concentrations of glucose (P < .01), insulin (P = .043), and NEFA (P = .041), more rapid elimination rates (P = .080, <.01 and .047 respectively), and shorter half-lives (P = .040, <.01 and .032) of these metabolites.Conclusions and Clinical ImportanceSupplementation with antioxidants before calving resulted in greater insulin sensitivity after calving, thereby suggesting the role of OS in the development of IR in cattle and the potential benefits of antioxidant supplementation in minimizing the consequences of negative energy balance
PB Wiley
YR 2016
FD 2016-03-12
LK http://hdl.handle.net/10347/16254
UL http://hdl.handle.net/10347/16254
LA eng
NO Abuelo, A., Alves-Nores, V., Hernandez, J., Muiño, R., Benedito, J.L. and Castillo, C. (2016), Effect of Parenteral Antioxidant Supplementation During the Dry Period on Postpartum Glucose Tolerance in Dairy Cows. Journal of Veterinary Internal Medicine, 30: 892–898. doi: 10.1111/jvim.13922
NO Funded byBritish Society for Animal ScienceSpanish Ministry of Education. Grant Number: AP2010-0013
DS Minerva
RD 24 abr 2026