RT Journal Article
T1 The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes
A1 Nieto Fontarigo, Juan José
A1 Salgado Castro, Francisco Javier
A1 San-José, M. E.
A1 Cruz, M. J.
A1 Casas-Fernández, A.
A1 Gómez-Conde, M. J.
A1 Valdés Cuadrado, Luis
A1 García González, Miguel Ángel
A1 Arias Crespo, María del Pilar
A1 Nogueira, M.
A1 González Barcala, Francisco Javier
K1 Asthma
K1 Monocytes
K1 CD14 (−159 C/T) SNP
K1 sCD14
AB LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH1-differentiation, counteracting the TH2-driven asthma. Therefore, CD14 modulation could alter the TH2-differentiation and should be taken into account when studying asthma. To analyse the alteration in CD14 levels and its association with CD14 (−159 C/T) SNP (rs2569190) in Caucasian adults with stable allergic asthma, we performed a cross-sectional study (277 healthy subjects vs. 277 patients) where clinical parameters, CD14 values and the CD14 (−159 C/T) SNP were studied. Apart from typical biomarkers, we found an increment of neuron-specific enolase (NSE) in allergic asthma, probably linked to monocyte activity. Indeed, we evidenced increased monocyte numbers, but lower CD14 expression and normalised sCD14 values in patients. Moreover, we noticed an association of the T allele (P = 0.0162) and TT genotype (P = 0.0196) of the CD14 SNP with a decreased risk of allergic asthma and augmented sCD14 levels. In conclusion, monocyte CD14 expression and normalized sCD14 values were reduced in stable state asthmatics, and this could be related to the presence of an expanded CD14low monocyte subset. This study also demonstrates that the CD14 (−159 C/T) polymorphism is a risk factor for moderate-severe allergic asthma in adult Caucasians
PB Springer Nature
SN 2045-2322
YR 2018
FD 2018-03-07
LK http://hdl.handle.net/10347/17403
UL http://hdl.handle.net/10347/17403
LA eng
NO Nieto-Fontarigo JJ, Salgado FJ, San-José ME, Cruz MJ, Casas-Fernández A, Gómez-Conde MJ, Valdés-Cuadrado L, García-González MÁ, Arias P, Nogueira M, González-Barcala FJ.The CD14 (-159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes.Sci Rep. 2018 Mar 7;8(1):4147. doi: 10.1038/s41598-018-20483-1.
NO This study was funded by grants from Sociedad Española de Neumología y Cirugía Torácica, (SEPAR) (121/2012) and Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (Fondo de Investigación Sanitaria, FIS; co-financed by European Union ERDF funds) (PI13/02046). JJNF is a recipient of a Xunta de Galicia Fellowship (Co-financed by European Social Fund (ESF))
DS Minerva
RD 26 abr 2026