RT Journal Article
T1 Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities
A1 Vizoso, Francisco J.
A1 Eiro, Noemi
A1 Costa, Luis
A1 Esparza, Paloma
A1 Landín Pérez, Mariana
A1 Díaz Rodríguez, Patricia
A1 Schneider, Jose
A1 Pérez Fernández, Román
K1 Regenerative medicine
K1 Aging diseases
K1 Diabetes
K1 Lupus
K1 Secretome
K1 Conditioned medium
K1 Extracellular vesicles
K1 Exosomes
AB Mesenchymal stem cells (MSCs) are present in all organs and tissues, playing a well-known function in tissue regeneration. However, there is also evidence indicating a broader role of MSCs in tissue homeostasis. In vivo studies have shown MSC paracrine mechanisms displaying proliferative, immunoregulatory, anti-oxidative, or angiogenic activity. In addition, recent studies also demonstrate that depletion and/or dysfunction of MSCs are associated with several systemic diseases, such as lupus, diabetes, psoriasis, and rheumatoid arthritis, as well as with aging and frailty syndrome. In this review, we hypothesize about the role of MSCs as keepers of tissue homeostasis as well as modulators in a variety of inflammatory and degenerative systemic diseases. This scenario opens the possibility for the use of secretome-derived products from MSCs as new therapeutic agents in order to restore tissue homeostasis, instead of the classical paradigm “one disease, one drug”.
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21197
UL http://hdl.handle.net/10347/21197
LA eng
NO Vizoso, F.J.; Eiro, N.; Costa, L.; Esparza, P.; Landin, M.; Diaz-Rodriguez, P.; Schneider, J.; Perez-Fernandez, R. Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities. Int. J. Mol. Sci. 2019, 20, 3738
NO This study was supported by Instituto de Salud Carlos III (PI17/02236) to F.J.V., and by Fundación para la Investigación en Células Madre Uterinas (FICEMU) to F.J.V and R.P.-F.
DS Minerva
RD 24 abr 2026