RT Journal Article
T1 Extracellular vesicles in the transfusion medicine field: The potential of proteomics
A1 Hermida Nogueira, Lidia
A1 García Alonso, Ángel
K1 Extracellular vesicles
K1 Proteomics
K1 Transfusion medicine
AB In transfusion centres, blood components are divided and stored following specific guidelines. The storage temperature and time vary among the blood cells but all of them release extracellular vesicles (EVs) under blood bank conditions. The clinical impact of such vesicles in blood components for transfusion is an object of debate, but should be considered and is being investigated. In this context, proteomics is an excellent tool to study the cargo and composition of EVs derived from red blood cells and platelets, since such vesicles are enriched in lipids and proteins. The development of quantitative mass spectrometry techniques and the evolution of bioinformatics have allowed the identification of novel EVs biomarkers for different diseases. In this context, the application of high coverage proteomic tools to the analysis of EVs in the transfusion medicine field would provide information about storage lesions and possible transfusion adverse reactions. This viewpoint article approaches the potential of proteomics to investigate the impact of EVs in blood bank transfusion components, especially red blood cells and platelets
PB Wiley
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26625
UL http://hdl.handle.net/10347/26625
LA eng
NO Hermida-Nogueira, L, García, Á. Viewpoint: Extracellular vesicles in the transfusion medicine field: The potential of proteomics. Proteomics. 2021; 21:e2000089. https://doi.org/10.1002/pmic.202000089
NO The authors acknowledge support given by the Spanish Ministry of Science and Innovation [grant no. PID2019-108727RB-I00], co-funded by the European Regional Development Fund (ERDF). Financial support from the Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (Centro Singular de investigación de Galicia accreditation 2019–2022; predoctoral grant 2018 Call) and the European Regional Development Fund (ERDF) is also gratefully acknowledged
DS Minerva
RD 4 may 2026