RT Dissertation/Thesis
T1 Quality-by-design approach for the development of lipid-based nanosystems for anti-mycobacterial therapy
A1 Rouco Taboada, Helena
K1 Lipid nanoparticles
K1 Quality-by-design
K1 Artificial Intelligence
K1 Antibiotics
AB In this work, we rationally developed a lipid-based nanotechnological platform for hydrophobic anti-mycobacterial drugs. For this purpose, Artificial Intelligence tools were employed to assist formulation development, from the initial design to its conversion into a solid dosage form. Reproducible nanocarriers exhibiting suitable properties were achieved through a simple and robust procedure. Furthermore, the analysis of their in vitro performance revealed promising results in terms of permeability, cell uptake and selective intracellular release. Thus demonstrating the potential of these nanosystems to treat intestinal intracellular infections, increasingly related with Crohn´s disease development.
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26059
UL http://hdl.handle.net/10347/26059
LA eng
DS Minerva
RD 28 abr 2026