RT Journal Article T1 Cognitive-behavioral treatment with behavioral activation for smokers with depressive symptomatology: study protocol of a randomized controlled trial A1 Becoña Iglesias, Elisardo A1 Martínez Vispo, Carmela A1 Senra Rivera, María del Carmen A1 López Durán, Ana A1 Rodríguez Cano, Rubén Agustín A1 Fernández del Río, Elena K1 Smoking cessation K1 Depressive symptoms K1 Behavioral activation K1 Randomized controlled trial AB BackgroundSmoking is an important risk factor for mental health-related problems. Numerous studies have supported a bi-directional association between cigarette smoking and depression. Despite the advances in understanding the comorbidity between both problems, the most effective psychological treatment that simultaneously targets smoking and depressive symptomatology remains unclear. The objective of this study is to assess the effectiveness of a cognitive-behavioral intervention for smoking cessation with components of behavioral activation for managing depressed mood.MethodA single blind, three-arm, superiority randomized controlled trial is proposed. Participants will be smokers over 18 years old, who smoke at least 8 cigarettes per day. Participants will be randomized to one of three conditions, using a 2:2:1 allocation ratio: 1) standard cognitive-behavioral smoking cessation treatment; 2) standard cognitive-behavioral smoking cessation treatment plus behavioral activation; or 3) a three-month delayed treatment control group. The primary outcome measures will be biochemically verified point-prevalence abstinence (carbon monoxide in expired air) and significant change from baseline in depressive symptoms to the end of treatment, and at the 3-, 6-, and 12-month follow-up.DiscussionThis study aims to assess the efficacy of a cognitive-behavioral intervention with behavioral activation components for smoking cessation and depressive symptoms, compared to a standard cognitive-behavioral intervention to quit smoking. As the relation between depressive symptoms, even at subclinical levels, and quitting smoking difficulties is well known, we expect that such intervention will allow obtaining higher abstinence rates, lower relapse rates, and mood improvement PB BMC YR 2017 FD 2017 LK http://hdl.handle.net/10347/22383 UL http://hdl.handle.net/10347/22383 LA eng NO Becoña, E., Martínez-Vispo, C., Senra, C. et al. Cognitive-behavioral treatment with behavioral activation for smokers with depressive symptomatology: study protocol of a randomized controlled trial. BMC Psychiatry 17, 134 (2017). https://doi.org/10.1186/s12888-017-1301-7 NO This research was supported by the Spanish Ministerio de Economía y Competitividad (Project reference: PSI2015–66755-R) and by FEDER (European Regional Development Fund) DS Minerva RD 30 abr 2026