RT Journal Article
T1 Efficacy of different formulations of nystatin in an experimental model of oral candidiasis in sialoadenectomized rats
A1 Pérez-Sayáns García, Mario
A1 Beiro-Fuentes, Renee
A1 Otero Rey, Eva María
A1 Chamorro Petronacci, Cintia Micaela
A1 Gándara Vila, Pilar
A1 Somoza Martín, José Manuel
A1 García García, Abel
A1 Blanco Carrión, Andrés
K1 Experimental models
K1 Salivary glands
K1 Nystatine
K1 C-albicans
K1 Oral candidiasis
AB Background/purpose: Oral candidiasis is the most common fungal infection of the oral cavity and has become a focus of attention in recent years because of its association with highly topical immunosuppressive conditions. The aims of this study were to determine the value of microbiological, clinical and histological parameters of Candida albicans colonisation of the dorsal tongue surface as indicators of disease severity, and to evaluate therapeutic response to different formulations of nystatin. Materials and methods: We used 84 males, 2-month-old SpragueeDawley sialoadenectomized rats. Different formulations of nystatin were used to evaluate the therapeutic response. The animals were randomized to 2 groups with each of 42 animals and received the experimental treatments from day 17e22. Results: 100% of the rats showed evidence of infection. At 5 and 10 days of starting treatment with nystatin þ chitosan, and at 10 days of starting nystatin þ orabase, the number of animals with positive dorsal tongue culture decreased significantly (p < 0.05), acting the Nystatin þ chitosan more rapidly against Candida. In the control group, the percentage of normal papillae on day 22 and 27 was 83.33% (SDZ1.50) and 79.08% (SDZ2.30), respectively. Significant differences were observed in the mean O’Grady score at 5 and 10 days (p < 0.0001). Conclusion: The model has been shown to be effective in inducing infection, and that the combination of nystatin and chitosan yielded the best therapeutic outcomes at both 5 and 10 days after infection.
PB Elsevier
SN 1991-7902
YR 2021
FD 2021
LK https://hdl.handle.net/10347/44219
UL https://hdl.handle.net/10347/44219
LA eng
NO Pérez-Sayáns, M., Beiro-Fuentes, R., Otero-Rey, E. M., Chamorro-Petronacci, C. M., Gándara-Vila, P., Somoza-Martín, J. M., García-García, A., & Blanco-Carrión, A. (2021). Efficacy of different formulations of nystatin in an experimental model of oral candidiasis in sialoadenectomized rats. Journal of Dental Sciences, 16(1), 123–130. https://doi.org/10.1016/j.jds.2020.05.031
DS Minerva
RD 28 abr 2026