RT Journal Article
T1 Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin
A1 Garrido Novelle, Marta
A1 Vázquez Villar, María Jesús
A1 Martinello, Kátia da Boit
A1 Sánchez Garrido, Miguel A.
A1 Tena Sempere, Manuel
A1 Diéguez González, Carlos
K1 Developmental biology
K1 Feeding behaviour
AB It is currently accepted that ambient, non-genetic factors influence perinatal development and evoke structural and functional changes that may persist throughout life. Overfeeding and androgenization after birth are two of these key factors that could result in “metabolic imprinting” of neuronal circuits early in life and, thereby, increase the body weight homeostatic “set point”, stimulate appetite and result in obesity. Our aim was to determine the influence of these obesogenic factors on the response to ghrelin. We observed the expected orexigenic effect of ghrelin regardless of the nutritional or hormonal manipulations to which the animals were subjected to at early postnatal development and this effect remained intact at later stages of development. In fact, ghrelin responses increased significantly when the animals were subjected to one of the two manipulations, but not when both were combined. An increased response to ghrelin could explain the obese phenotype displayed by individuals with modified perinatal environment.
PB Nature Publishing Group
YR 2015
FD 2015
LK http://hdl.handle.net/10347/23053
UL http://hdl.handle.net/10347/23053
LA eng
NO Novelle, M., Vázquez, M., Martinello, K. et al. Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin. Sci Rep 4, 4855 (2015). https://doi.org/10.1038/srep04855
NO This work has been supported by grants from Ministerio de Educacion y Ciencia (CD: BFU2011-29102) and Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. The research leading to these results has also received funding from the European Community's Seventh Framework Programme under the following grant: CD: FP7/2007-2013: n° 245009: NeuroFAST
DS Minerva
RD 28 abr 2026