RT Dissertation/Thesis
T1 Development of ligands for the platelet receptor CLEC-2
A1 Morán Lara, Luis Arturo
K1 CLEC-2
K1 platelet
K1 ligands
AB Platelets are anucleate cells derived from megakaryocytes, which play animportant role in the regulation of haemostasis and thrombosis at the injury site; however, they are also involved inother physiological processes such as inflammation, during which they interact with other immune cells includingleukocytes. However, certain chronic inflammatory diseases may lead to an aberrant prothrombotic response,known as thromboinflammation. This process is modulated by certain platelet immune receptors, including CLEC-2,a C-type lectin-like type II transmembrane receptor.In this study we searched for novel ligands for the platelet receptor CLEC-2. We identified a new platelet agonist,called Katacine, which induces strong platelet aggregation through CLEC-2. We also developed multimericnanobodies against this receptor and we suggested that tetrameric structures are needed to induce plateletaggregation, while lower order of oligomerisation are unable to induce platelet aggregation. But able to preventplatelet aggregation. The novel tools will facilitate further research on CLEC-2 function and the mode of activationof CLEC-2.
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29300
UL http://hdl.handle.net/10347/29300
LA eng
DS Minerva
RD 23 abr 2026