RT Journal Article
T1 Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
A1 Barca Mayo, Olga
A1 Pons-Espinal, Meritxell
A1 Follert, Philipp
A1 Armirotti, Andrea
A1 Berdondini, Luca
A1 De Pietri Tonelli, Davide
K1 Ritmos circadianos
K1 Astrocitos
K1 Comportamiento
K1 Memoria
K1 GABA
AB Circadian rhythms are controlled by a network of clock neurons in the central pacemaker, the suprachiasmatic nucleus (SCN). Core clock genes, such as Bmal1, are expressed in SCN neurons and in other brain cells, such as astrocytes. However, the role of astrocytic clock genes in controlling rhythmic behaviour is unknown. Here we show that ablation of Bmal1 in GLAST-positive astrocytes alters circadian locomotor behaviour and cognition in mice. Specifically, deletion of astrocytic Bmal1 has an impact on the neuronal clock through GABA signalling. Importantly, pharmacological modulation of GABAA-receptor signalling completely rescues the behavioural phenotypes. Our results reveal a crucial role of astrocytic Bmal1 for the coordination of neuronal clocks and propose a new cellular target, astrocytes, for neuropharmacology of transient or chronic perturbation of circadian rhythms, where alteration of astrocytic clock genes might contribute to the impairment of the neurobehavioural outputs such as cognition.
PB nature Research
SN 2041-1723
YR 2017
FD 2017-02-10
LK https://hdl.handle.net/10347/38624
UL https://hdl.handle.net/10347/38624
LA eng
NO Barca-Mayo, O., Pons-Espinal, M., Follert, P., Armirotti, A., Berdondini, L., De Pietri Tonelli, D. (2017). Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signaling. “Nature Communications”, vol. 8, 14336.
NO Descrición física:El documento consta de 14 páxinas numeradas electrónicamente (14336) e inclúe gráficos, ilustracións e táboas.Información adicional sobre a/s Persoa/s autora/s:Este traballo foi realizado por Olga Barca-Mayo e colaboradores, pertencendo á súa liña de investigación sobre ritmos circadianos e astrocitos.Presentación do traballo:Resultados deste artigo foron presentados en múltiples congresos internacionais, incluíndo a Gordon Research Conference en Gerona, España (2015), e o encontro anual da Japan Neuroscience Society en Kobe, Xapón (2015).Fórmula sobre copyright:Este artigo foi publicado baixo a licenza Creative Commons Attribution 4.0 (CC BY 4.0), que permite o uso, distribución e reprodución en calquera medio, sempre que se acredite ao autor orixinal e á fonte. A versión definitiva está dispoñible en: https://doi.org/10.1038/ncomms14336.
NO European Research Executive Agency (REA) through the FP7-PEOPLE-2014-IEF ‘ASTROCLOCK’ (629867).
NO Fundación Cariplo: 2015-0590 Role Of The Astrocyte Clock In Neurodegeneration And Brain Aging
DS Minerva
RD 24 abr 2026