RT Journal Article
T1 Neuropsychiatric symptoms after liver transplantation in a 65-year-old male patient
A1 Bugallo Carrera, César
A1 Facal Mayo, David
A1 Domínguez Lenogue, Cristina
A1 Álvarez Vidal, Vanessa
A1 Gandoy Crego, Manuel
A1 Caamaño Ponte, José Luis
K1 Liver transplant
K1 Immunosuppression
K1 Neurotoxicity
K1 Psychosis
K1 Depression
K1 Anxiety
K1 Cognitive intervention
AB The development of immunosuppressants has been key for the advancement of solidorgan transplant surgery. Specifically, cyclosporine, tacrolimus, or everolimus have significantlyincreased the survival rate of patients by reducing the risk of a rejection of the transplanted organand limiting graft-versus-host disease. We report the case of a 65-year-old man who, after undergoinga liver transplantation and receiving an immunosuppressive treatment with cyclosporineand everolimus, presented severe obsessive, psychotic, and behavioral symptoms over the pastthree years, and describe the pharmacological and non-pharmacological interventions implementedagainst these symptoms. In this case, the immunosuppressants used have been cyclosporine and,preferably, everolimus. On the other hand, potential adverse reactions to the treatment have beenobserved, including neuropsychiatric symptoms such as tremor, anxiety, dysthymia, psychosis, andbehavioral disorders, which make it necessary to use corrective psychoactive drugs such as benzodiazepines,antidepressants, and antipsychotics, combined with non-pharmacological interventions. Atransversal approach, from the medical and psychosocial disciplines, facilitates success in managingneuropsychiatric symptoms after soft organ transplants
PB MDPI
YR 2022
FD 2022
LK http://hdl.handle.net/10347/30815
UL http://hdl.handle.net/10347/30815
LA eng
NO Bugallo-Carrera, C.; Facal, D.; Domínguez-Lenogue, C.; Álvarez-Vidal, V.; Gandoy-Crego, M.; Caamaño-Ponte, J. Neuropsychiatric symptoms after liver transplantation in a 65-year-old male patient. Brain Sci. 2022, 12, 1721
DS Minerva
RD 23 abr 2026