RT Journal Article
T1 Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing
A1 Amato, Giovanni
A1 Grimaudo, Maria Aurora
A1 Álvarez Lorenzo, Carmen
A1 Concheiro Nine, Ángel Joaquín
A1 Carbone, Claudia
A1 Bonaccorso, Angela
A1 Puglisi, Giovanni
A1 Musumeci, Teresa
K1 Hyaluronan
K1 ε-polylysine
K1 Berberine
K1 Chronic wounds
K1 Nanogels
AB Physiological wound healing process can be delayed in the presence of certain pathologies, such as diabetes or cancer. In this perspective, the aim of this study was to design a new nanogel platform of hyaluronan, poly-L-lysine and berberine suitable for wound treatment. Two different nanogel formulations were selected after a first formulation screening. They were prepared by adding dropwise 2 mg/mL hyaluronan aqueous solution (200 or 700 kDa) to 1.25 mg/mL poly-L-lysine aqueous solution. Blank nanogels formulated with 200 kDa HA resulted stable after freeze-drying with dimensions, polydispersity index and zeta potential of 263.6 ± 13.1 nm, 0.323 ± 0.029 and 32.7 ± 3.5 mV, respectively. Both blank and berberine-loaded nanogels showed rounded-shape structures. Loaded nanogels released nearly 50% of loaded berberine within 45 min, whereas the remaining 50% was released up to 24 h in vitro. Both, blank and berberine-loaded nanogels were able to completely close the fibroblasts gap in 42 h
PB MDPI
YR 2021
FD 2021
LK http://hdl.handle.net/10347/24191
UL http://hdl.handle.net/10347/24191
LA eng
NO Amato, G.; Grimaudo, M.A.; Alvarez-Lorenzo, C.; Concheiro, A.; Carbone, C.; Bonaccorso, A.; Puglisi, G.; Musumeci, T. Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing. Pharmaceutics 2021, 13, 34
NO This work was supported by a grant from the Italian Ministry of Research [Grant PRIN 2017 #20173ZECCM Tracking biological barriers to antigen delivery by nanotechnological vaccines (NanoTechVax)], by Research Funding for the University of Catania [Piano per la Ricerca 2016–2018–Linea di intervento 2 “Dotazione Ordinaria], by MINECO Spain [SAF2017-83118-R], FEDER and Xunta de Galicia Spain [ED431C 2020/17]
DS Minerva
RD 3 may 2026