RT Journal Article T1 Cognitive reserve and mental health in cognitive frailty phenotypes: Insights from a study with a Portuguese sample A1 Miguel Gaspar, Pedro A1 Campos Magdaleno, María A1 Pereiro Rozas, Arturo X. A1 Facal Mayo, David A1 Juncos Rabadán, Onésimo K1 Subjective cognitive decline K1 Mild cognitive impairment K1 Education K1 Social-support K1 Leisure activities K1 Affective disorders AB Background: Research on prevalence of cognitive frailty phenotypes incommunity-dwelling older adults in different countries is important toestimate their prevalence and to determine the influence of cognitive reserveand mental health in order to prevent frailty. The aims of this study were toestimate the prevalence of reversible and potentially reversible cognitivefrailty (R-CF, PR-CF) in a Portuguese sample of old adults and explore theassociations between these phenotypes and demographic, comorbidity,social support, cognitive reserve and mental health factors.Methods: We assessed frailty (Fried criteria) in 250 community-dwellingolder adults (179 women) aged 60 years or over (mean 71.04 years) withoutdementia, neurological or psychiatric disorders. Subjective cognitive declineand Mild cognitive impairment were diagnosed according to standardcriteria. The questionnaires Charlson Index, Medical Outcomes Study SocialSupport, Cognitive Reserve Index and General Health were used for assessingcomorbidity, social support, cognitive reserve and mental health, respectively.Results: Prevalence of R-CF was 14%, and that of PR-CF, 15.2%. Cognitivefrailty profiles differed significantly in relation to education, comorbidity,mental health, and cognitive reserve, but not in age or sex. Multivariate logisticregression showed that age, sex, comorbidity, social support, mental health,and cognitive reserve together predicted R-CF and PR-CF (90% specificity 75%sensitivity) with significant OR for mental health and cognitive reserve.Discussion: Cognitive reserve and mental health are important factorspredicting R-CF and PR-CF. We recommend assessing these factors for earlydetection of cognitive frailty and promoting psychological well-being andlifestyles that increase cognitive reserve in adults PB Frontiers Media SN 1664-1078 YR 2022 FD 2022 LK http://hdl.handle.net/10347/29964 UL http://hdl.handle.net/10347/29964 LA eng NO Gaspar PM, Campos-Magdaleno M, Pereiro AX, Facal D and Juncos-Rabadán O (2022) Cognitive reserve and mental health in cognitive frailty phenotypes: Insights from a study with a Portuguese sample. Front. Psychol. 13:968343 NO This work was financially supported by ERDF funds through the National Research Agency (Spanish Ministry of Science, Innovation and Universities; Projects Ref. PSI2017-89389-C2-1-R and PID2020-114521RB-C21) and the Galician Government [GRC (GI-1807-USC); Ref: ED431-2017/27; ED431C-2021/04]; all with ERDF/FEDER funds DS Minerva RD 24 abr 2026