RT Journal Article
T1 Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity
A1 Fagundo, Ana Beatriz
A1 Jiménez Murcia, Susana
A1 Giné Bartolomé, C.
A1 Agüera, Zaida
A1 Sauchelli, Sarah
A1 Pardo Pérez, María
A1 Crujeiras Martínez, Ana Belén
A1 Granero, Roser
A1 Baños, Rosa M.
A1 Botella, Cristina
A1 Torre, Rafael de la
A1 Fernández Real, Jose M.
A1 Fernández García, J. C.
A1 Frühbeck, Gema
A1 Rodríguez, A.
A1 Mallorquí Bagué, N.
A1 Tárrega, S.
A1 Tinahones Madueño, Francisco José
A1 Rodríguez, R.
A1 Ortega, F.
A1 Menchón, José M.
A1 Casanueva Freijo, Felipe
A1 Fernández Aranda, Fernando
K1 Cognitive control
K1 Decision
K1 Predictive markers
AB Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use.
PB Nature Publishing Group
SN 2045-2322
YR 2016
FD 2016
LK http://hdl.handle.net/10347/22971
UL http://hdl.handle.net/10347/22971
LA eng
NO Fagundo, A. B., Jiménez-Murcia, S., Giner-Bartolomé, C., Agüera, Z., Sauchelli, S., Pardo, M., ... & De La Torre, R. (2016). Modulation of irisin and physical activity on executive functions in obesity and morbid obesity. Scientific reports, 6(1), 1-9.
NO This work was supported by Instituto de Salud Carlos III (ISCIII)[FIS PI14/00290 and European Regional Development Fund (ERDF)-“a way to Build Europe”-// FONDOS FEDER “una manera de hacer Europa”] AGAUR (2009SGR1554, 2009SGR718); ABF was supported by Ministerio de Ciencia e Innovación Subprograma Juan de la Cierva (JCI-2011-09248); CGB was supported by Ayudas Predoctorales de Formación en Investigación en Salud-PFIS (FI12/00470). ABC is funded by the ISCIII through a research contract “Sara Borrell” (C09/00365). MP is a Miguel Servet Fellow (ISCIII/SERGAS). JCFG is recipient of a research contract from Servicio Andaluz de Salud (SAS) (B-0033-2014). CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and CIBER Salud Mental (CIBERsam), are supported by ISCIII
DS Minerva
RD 24 abr 2026