RT Journal Article
T1 In Vivo Evaluation of the Chronic Oral Toxicity of the Marine Toxin Palytoxin
A1 Boente Juncal, Andrea
A1 Raposo García, Sandra
A1 Vale González, María del Carmen
A1 Louzao Ojeda, María del Carmen
A1 Otero Fuertes, María Paz
A1 Botana López, Luis Miguel
K1 Palytoxin
K1 Marine toxins
K1 In vivo toxicity
K1 EFSA
K1 Risk assessment
K1 Sodium-potassium ATPase
K1 LD50
K1 NOAEL
AB Palytoxin (PLTX) is one of the most poisonous substances known to date and considered as an emergent toxin in Europe. Palytoxin binds to the Na+-K+ ATPase, converting the enzyme in a permeant cation channel. This toxin is known for causing human fatal intoxications associated with the consumption of contaminated fish and crustaceans such as crabs, groupers, mackerel, and parrotfish. Human intoxications by PLTX after consumption of contaminated fishery products are a serious health issue and can be fatal. Different reports have previously explored the acute oral toxicity of PLTX in mice. Although the presence of palytoxin in marine products is currently not regulated in Europe, the European Food Safety Authority expressed its opinion on PLTX and demanded assessment for chronic toxicity studies of this potent marine toxin. In this study, the chronic toxicity of palytoxin was evaluated after oral administration to mice by gavage during a 28-day period. After chronic exposure of mice to the toxin, a lethal dose 50 (LD50) of 0.44 µg/kg of PLTX and a No-Observed-Adverse-Effect Level (NOAEL) of 0.03 µg/kg for repeated daily oral administration of PLTX were determined. These results indicate a much higher chronic toxicity of PLTX and a lower NOAEL than that previously described in shorter treatment periods, pointing out the need to further reevaluate the levels of this compound in marine products
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23594
UL http://hdl.handle.net/10347/23594
LA eng
NO Boente-Juncal, A.; Raposo-García, S.; Vale, C.; Louzao, M.C.; Otero, P.; Botana, L.M. In Vivo Evaluation of the Chronic Oral Toxicity of the Marine Toxin Palytoxin. Toxins 2020, 12, 489
NO The research leading to these results has received funding from the following European Regional Development Fund (FEDER) cofounded grants. From Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01). From European Union POCTEP 0161-Nanoeaters-1-E-1, Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069- EMERTOX
DS Minerva
RD 29 abr 2026