RT Journal Article
T1 Reference Intervals for Trace Elements in Canine Plasma
A1 Larrán Franco, Belén
A1 López Alonso, María Marta
A1 Miranda Castañón, Marta Inés
A1 Suárez Rey, María Luisa
A1 Orjales Galdo, Inmaculada
K1 Minerals
K1 Metals
K1 Toxic elements
K1 Heavy metals
K1 Canine
K1 ICP-MS
AB Trace elements are essential for organisms, and their involvement in diverse diseases is increasingly recognised. Interest is increasing in veterinary medicine, particularly in relation to canine diseases. However, reference intervals for trace elements in dogs remain scarce. Plasma samples from 140 dogs were analysed by inductively coupled plasma mass spectrometry to determine the levels of 13 trace elements. Reference intervals (µg/L) were established for the following 12 elements: As, 0.417–8.17; Co, 0.039–1.33; Cr, 2.41–13.3; Cu, 296–790; Fe, 846–3643; Hg, 0.235–2.33; Ni, 0.567–9.04; Mn, 1.90–7.28; Mo, 1.43–12.7; Pb, 0.285–2.82; Se, 200–434; and Zn, 415–1095. However, Cd was below the limit of quantification in 77% of the samples. No differences in trace element concentrations were observed in relation to breed or reproductive status. Statistically significant differences were found in relation to sex (Cu, Mo, Zn), age (Co, Cu, Mo, Mn, Se, Zn), and size (Cu, Mo, Se, Zn); however, the magnitude of these effects varied among elements and was generally weak. Nevertheless, these factors should be considered when assessing trace element status. These reference intervals constitute an important resource for both clinical evaluation and future research.
PB MDPI
YR 2026
FD 2026-01-15
LK https://hdl.handle.net/10347/46156
UL https://hdl.handle.net/10347/46156
LA eng
NO Larrán, B., López-Alonso, M., Miranda, M., Suárez, M. L., & Orjales, I. (2026). Reference Intervals for Trace Elements in Canine Plasma. Animals, 16(2), 264. https://doi.org/10.3390/ani16020264
NO This research was carried out within the IMedA Research group of the University of Santiago de Compostela (USC) that belong to the “Grupo de Potencial Crecimiento” funded by GAIN (Axencia Galega de Innovación; grant number ED431B 2023/008).
DS Minerva
RD 7 jun 2026