RT Journal Article
T1 Straightforward Assembly of Benzoxepines by Means of a Rhodium(III)-Catalyzed C–H Functionalization of o-Vinylphenols
A1 Seoane Fernández, Andrés
A1 Casanova González, Noelia
A1 Quiñones, Noelia
A1 Mascareñas Cid, José Luis
A1 Gulías Costa, Moisés
AB Readily available o-vinylphenols undergo a formal (5 + 2) cycloaddition to alkynes when treated with catalytic amounts of [Cp*RhCl2]2 and Cu(OAc)2. The reaction, which involves the cleavage of the terminal C–H bond of the alkenyl moiety, generates highly valuable benzoxepine skeletons in a practical, versatile, and atom-economical manner. Using carbon monoxide instead of an alkyne as reaction partner leads to coumarin products which formally result from a (5 + 1) cycloaddition
PB American Chemical Society
SN 0002-7863
YR 2014
FD 2014
LK http://hdl.handle.net/10347/18478
UL http://hdl.handle.net/10347/18478
LA eng
NO Seoane, A., Casanova, N., Quiñones, N., Mascareñas, J., & Gulías, M. (2014). Straightforward Assembly of Benzoxepines by Means of a Rhodium(III)-Catalyzed C–H Functionalization of o-Vinylphenols. J. Am. Chem. Soc., 136, 3, 834-837. DOI: 10.1021/ja410538w
NO This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/doi/10.1021/ja410538w
NO We are thankful for the financial support provided by theSpanish Grants (SAF2010-20822-C02 and CSD2007-00006Consolider Ingenio 2010), the ERDF and the Xunta de GaliciaGrants GRC2010/12, GR2013-041, INCITE09 209084PR andEM2013/036. M.G thanks Xunta de Galicia for a Parga Pondalcontract
DS Minerva
RD 23 abr 2026