RT Journal Article
T1 Hesperidin as a neuroprotective agent: a review of animal and clinical evidence
A1 Hajialyani, Marziyeh
A1 Farzaei, Mohammad Hosein
A1 Echeverría, Javier
A1 Nabavi, Seyed Mohammad
A1 Uriarte Villares, Eugenio
A1 Sobarzo Sánchez, Eduardo Marcelo
K1 Hesperidin
K1 Neuroprotective mechanisms
K1 Parkinson’s disease
K1 Alzheimer’s disease
K1 Huntington’s disease
AB Neuroprotection is the preservation of function and networks of neural tissuesfrom damages caused by various agents, as well as neurodegenerative diseases such asParkinson’s, Alzheimer’s, Huntington’s diseases, and multiple sclerosis. Hesperidin, a flavanoneglycoside, is a natural phenolic compound with a wide range of biological effects. Mountingevidence has demonstrated that hesperidin possesses inhibitory effect against development ofneurodegenerative diseases. Our review discusses neuropharmacological mechanisms for preventiveand therapeutic effects of hesperidin in neurodegenerative diseases. In addition, the reviewexamines clinical evidence confirming its neuroprotective function. Various cellular and animalmodels specific to neurodegenerative diseases have been conducted to evaluate the underlyingneuropharmacological mechanisms of hesperidin. Neuroprotective potential of this flavonoid ismediated by improvement of neural growth factors and endogenous antioxidant defense functions,diminishing neuro-inflammatory and apoptotic pathways. Despite the various preclinical studies onthe role of hesperidin in the neurodegenerative diseases, less is known about its definite effect onhumans. A limited number of clinical trials showed that hesperidin-enriched dietary supplements cansignificantly improve cerebral blood flow, cognition, and memory performance. Further clinical trialsare also required for confirming neuroprotective efficacy of this natural flavonoid and evaluating itssafety profile
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/22629
UL http://hdl.handle.net/10347/22629
LA eng
NO Hajialyani, M.; Hosein Farzaei, M.; Echeverría, J.; Nabavi, S.M.; Uriarte, E.; Sobarzo-Sánchez, E. Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence. Molecules 2019, 24, 648
DS Minerva
RD 24 abr 2026