RT Journal Article
T1 Modulating osteoclasts with nanoparticles: A path for osteoporosis management?
A1 Rouco Taboada, Helena
A1 García García, Patricia
A1 Briffault del Castillo, Erik Brenden
A1 Díaz Rodríguez, Patricia
K1 Extracellular vesicles
K1 Nanoparticles
K1 Osteoclasts
K1 Osteoporosis
AB Osteoclasts are the cells responsible for the bone resorption process during boneremodeling. In a healthy situation, this process results from an equilibriumbetween new matrix formation by osteoblast and matrix resorption by osteoclast.Osteoporosis (OP) is a systemic bone disease characterized by a decreased bonemass density and alterations in bone microarchitecture, increasing fracture pre disposition. Despite the variety of available therapies for OP management there isa growing gap in its treatment associated to the low patients´ adherence owing toconcerns related with long-term efficacy or safety. This makes the developmentof new and safe treatments necessary. Among the newly developed strategies, theuse of synthetic and natural nanoparticles to modulate osteoclasts differentiation,activity, apoptosis or crosstalk with osteoblasts have arisen. Syntheticnanoparticles exert their therapeutic effect either by loading antiresorptive drugsor including molecules for osteoclasts gene regulation. Moreover, this controlover osteoclasts can be improved by their targeting to bone extracellular matrixor osteoclast membranes. Furthermore, natural nanoparticles, also known asextracellular vesicles, have been identified to play a key role in bone homeostasis.Consequently, these systems have been widely studied to control osteoblasts andosteoclasts under variable environments. Additionally, the ability to bioengineerextracellular vesicles has allowed to obtain biomimetic systems with desirablecharacteristics as drug carriers for osteoclasts. The analyzed information revealsthe possibility of modulating osteoclasts by different mechanisms through nanoparticles decreasing bone resorption. These findings suggest that controllingosteoclast activity using nanoparticles has the potential to improve osteoporosismanagement. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
PB Wiley
SN 1939-5116
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30770
UL http://hdl.handle.net/10347/30770
LA eng
NO Rouco, H., García-García, P., Briffault, E., & Diaz-Rodriguez, P. (2023). Modulating osteoclasts with nanoparticles: A path for osteoporosis management? WIREs Nanomedicine and Nanobiotechnology, e1885. https://doi.org/10.1002/wnan.1885
NO Patricia García-García acknowledges the University of La Laguna for the action “Recualificación de personal universitario: Margarita Salas para la formación de jóvenes doctores”. Helena Rouco acknowledges the University of Santiago de Compostela for the action “Recualificación de personal universitario: Margarita Salas para la formación de jóvenes doctores”. This work was funded by MCIN/AEI/10.13039/501100011033/FEDER, UE, (PID2021-127493OA-C22)
DS Minerva
RD 24 abr 2026