RT Book,_Section
T1 Structural Modifications on Natural-based Products: Synthetic Strategies and Biological Applications
A1 Fonseca, André
A1 Matos, Maria João Correia Pinto Carvalho de
A1 Vázquez Rodríguez, Saleta
A1 Viña Castelao, María Dolores
A1 Vilar Varela, Santiago
A1 Borges, Fernanda
A1 Santana Penín, María Lourdes
A1 Uriarte Villares, Eugenio
K1 Natural products
K1 Coumarins
K1 Resveratrol
K1 Chalcones
K1 Pharmacological applications
AB Coumarins are a class of heterocyclic compounds present in a significant quantity in several plants. The simplest coumarin, a benzene ring fused with a pyran-2-one heterocycle, was first discovered in the 19th century and since then, due to the synthetic accessibility and the biological properties of its derivatives, has been playing an important role in the Medicinal Chemistry field. In fact, coumarins have been previously described as anticancer, antiviral, anti-inflammatory, antimicrobial, enzymatic inhibitory and antioxidant agents.Another two interesting compounds found widely in nature are resveratrol derivatives and chalcones. Both families of compounds are known for having remarkable antioxidant activity, cardio- and neuroprotective effects, among other relevant biological properties. Therefore, we devised several synthetic strategies to incorporate these natural products in one compound, combining their potential as promising agents for the treatment of several illnesses. In our group, we have already synthesised multiple novel compounds incorporating into the coumarin scaffold the resveratrol or chalcones moieties with remarkable activities towards different pharmacological targets. In this work, we continue exploiting this strategy by incorporating different linkers at coumarin position 3, thus giving us a wide range of possibilities for new compounds
PB MDPI
SN 978-3-906980-55-3
YR 2015
FD 2015
LK http://hdl.handle.net/10347/25979
UL http://hdl.handle.net/10347/25979
LA eng
NO Fonseca, A., Matos, M.J., Vazquez-Rodriguez, S., Viña, D., Vilar, S., Borges, F., Santana, L. & Uriarte, E. (2015). Structural Modifications on Natural-based Products: Synthetic Strategies and Biological Applications. In J.A. Seijas, M.P. Vázquez Tato & S.K. Lin, Proceedings ECSOC-18: The 18Th International Electronic Conference On Synthetic Organic Chemistry: November 1-30, 2014. MDPI. doi: 10.3390/ecsoc-18-b023
DS Minerva
RD 28 abr 2026