RT Journal Article
T1 Gold(I)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans
A1 Faustino, Hélio
A1 Varela Sandá, Iván
A1 Mascareñas Cid, José Luis
A1 López García, Fernando
K1 Allenamides
K1 Cycloadditions
K1 Alkenes
K1 Aldehydes
K1 Tetrahydropyrans
AB Allenamides participate as two-carbon components in an intermolecular [2 + 2 + 2] cycloaddition with alkenes and aldehydes when treated with catalytic amounts of a phosphite gold complex. The reaction ishighly regio- and chemoselective, and works with different types of alkenes, including styrenes, enolethers or enamides, as well as with aromatic and aliphatic aldehydes. Accordingly, different types of 2,6-disubstituted tetrahydropyrans can be stereoselectively assembled in a single step from commercial or very accessible starting materials
PB Royal Society of Chemistry
SN 2041-6520
YR 2015
FD 2015-03-02
LK http://hdl.handle.net/10347/13247
UL http://hdl.handle.net/10347/13247
LA eng
NO Faustino, H., Varela, I., Mascareñas Cid, J.L. & López, F. (2015). Gold(I)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans. "Chemical Science", 6, 2903-2908 [10.1039/C5SC00295H]
NO This work was supported by the Spanish MINECO (SAF2013-41943-R, SAF2010-20822-C02), the ERDF, the European Research Council (Adv. Grant no. 340055) and the Xunta deGalicia (GRC2013-041). HF acknowledges the Fundação para a Ciência e Tecnologia(Portugal) and POPH/FSE for a PhD grant (SFRH/BD/60214/2009)
DS Minerva
RD 28 abr 2026