RT Journal Article
T1 Inhibition deficit in the spatial tendency of the response in multiple-domain amnestic mild cognitive impairment. An event-related potential study
A1 Cespón, Jesús
A1 Galdo Álvarez, Santiago
A1 Díaz Fernández, Fernando
K1 Event-related potentials (ERP)
K1 Mild cognitive impairment (MCI)
K1 Negativity central contralateral (N2cc)
K1 Negativity posterior contralateral (N2pc)
K1 Inhibitory control
K1 Stimulus-response compatibility tasks (SRC)
AB Longitudinal studies have shown that a high percentage of people with amnestic mild cognitive impairment (MCI) develop Alzheimer’s disease (AD). Prodromal AD is known to involve deficits in executive control processes. In the present study, we examined such deficits by recording EEG in 13 single-domain amnestic MCI (sdaMCI), 12 multiple-domain amnestic MCI (mdaMCI) and 18 healthy elderly (control group, CG) participants while they performed a Simon task. The Simon task demands deployment of executive processes because participants have to respond to non-spatial features of a lateralized stimulus and inhibit the more automatic spatial tendency of the response. We specifically focused on the negativity central contralateral (N2cc), an event-related potential (ERP) component related to brain activity that prevents the cross-talk between direction of spatial attention and manual response preparation. The reaction time (RT) was not significantly different among the three groups of participants. The percentage of errors (PE) was higher in mdaMCI than in CG and sdaMCI participants. In addition, N2cc latency was delayed in mdaMCI (i.e., delayed implementation of mechanisms for controlling the spatial tendency of the response). The N2cc latency clearly distinguished among mdaMCI and CG/sdaMCI participants (area under curve: 0.91). Longer N2cc was therefore associated with executive control deficits, which suggests that N2cc latency is a correlate of mdaMCI
PB Frontiers Media
YR 2015
FD 2015
LK http://hdl.handle.net/10347/21377
UL http://hdl.handle.net/10347/21377
LA eng
NO Cespón J, Galdo-Álvarez S and Díaz F (2015) Inhibition deficit in the spatial tendency of the response in multiple-domain amnestic mild cognitive impairment. An event-related potential study. Front. Aging Neurosci. 7:68
NO This study was funded by the Spanish Government: Ministerio de Economía y Competitividad (PSI2010-22224-C03-03); and by the Galician Government: Consellería de Economía e Industria (10 PXIB 211070 PR), and Consellería de Cultura, Educación e Ordenación Universitaria (Axudas de Apoio á etapa inicial de formación posdoutoral 2011-2015 (Plan I2C); Axudas para a Consolidación e Estruturación de unidades de investigación competitivas do sistema universitario de Galicia. Ref: CN 2012/033; with FEDER funds)
DS Minerva
RD 7 jun 2026