RT Dissertation/Thesis
T1 Nanocapsules containing immunomodulators and monoclonal antibodies for the treatment of lung cancer
A1 Berrecoso Cuña, Germán
K1 Nanotechnology
K1 nanocapsules
K1 protein corona
K1 immunomodulators
K1 monoclonal antibodies
K1 lung cancer
K1 NSCLC
AB The main objectives of this thesis were, first, to characterize the chemical,physicochemical, and biological composition following the Minimum Information about Nanomaterial Biocorona Experiments (MINBE) recommendations of blank polymeric NCs, second, to develop NCs loaded with chemotherapeutics and immunomodulators (STAT3 and TGF-β pathway inhibitors), and third, to develop a nanotechnology platform for the intracellular delivery of mAb (bevacizumab as a model mAb, and anti-KRASG12V mAb as therapeutic mAb).
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30311
UL http://hdl.handle.net/10347/30311
LA eng
DS Minerva
RD 30 abr 2026