RT Dissertation/Thesis
T1 The obestatin/GPR39 system: from satellite cell regulation to its applicability in Duchenne muscular dystrophy
A1 González Sánchez, Jessica
K1 Obestatin signalling
K1 Muscle satellite cell
K1 Duchenne muscular dystrophy
AB The obestatin/GPR39 system functions as a mediator of skeletal muscle determination, maintenance, and plasticity in physiological and pathological conditions. In satellite cells, the obestatin/GPR39 system acts as an autocrine factor regulating cell cycle progression and fate determination. In Duchenne muscular dystrophy, obestatin signalling addresses multiple pathways needed for phenotypic amelioration, including regulation of myofibre regeneration, activation of the slow oxidative myofibre program, regulation of proteasomal signalling, stabilization of the sarcolemma and induction of corrective autophagy. The results point to the obestatin/GPR39 system as a practical and effective target for future Duchenne muscular dystrophy therapies.
YR 2019
FD 2019
LK http://hdl.handle.net/10347/18662
UL http://hdl.handle.net/10347/18662
LA eng
DS Minerva
RD 26 abr 2026