RT Dissertation/Thesis
T1 Regulation of the ISG15 activity by SUMO
A1 Bouzaher, Yanis Hichem
K1 ISG15
K1 SUMO
AB ISG15 is a Ubiquitin-like protein that plays important functionsin different pathologies but these functions depend on thespecie, cell type, viral type and ISG15 form. How ISG15activities are regulated is unclear. Here we show that ISG15can be SUMOylated and interacts with SUMO in a non-covalentmanner. SUMOylation of ISG15 is triggered by different typesof stress as well as upon overexpression of the tumorsuppressor p14ARF. We show that ISG15 can be detected at thePML-NBs and that mutation of the SUMO binding sitespositively modulates its co-localization with PML-NBs. Finally,we show that the interaction of SUMO with ISG15 positivelymodulates the anti-apoptotic activity of ISG15 upon IFNtreatment, the pro-viral activity of ISG15 during VSV infection,and is required for proper mitochondria biogenesis.
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34233
UL http://hdl.handle.net/10347/34233
LA eng
DS Minerva
RD 28 abr 2026