RT Dissertation/Thesis
T1 Peptide Engineering: From Fluorescent Biomarkers to Bioorthogonal Catalysts
A1 González González, Carmen
K1 peptides
K1 non-aromatic
K1 fluorescence
K1 bioorthogonal
K1 catalysis
AB Fluorescent proteins have become essential tools for bioimaging, but recent discoveries suggest that peptides lacking aromatic residues can also exhibit fluorescence. This phenomenon, termed clusteroluminescence, arises from the spatial confinement of electron-rich functional groups, leading to electronic delocalization and the formation of emissive clusters. Understanding this mechanism can open new possibilities for non-aromatic fluorescent peptides as bioimaging tools. This project focuses on single alpha-helical peptides (SAHs), particularly the E-R/K alpha-helical motif, which consists of repeating anionic (Glu) and cationic (Lys/Arg) residues that stabilize the structure through salt bridges.
YR 2025
FD 2025
LK https://hdl.handle.net/10347/42900
UL https://hdl.handle.net/10347/42900
LA eng
DS Minerva
RD 24 abr 2026