RT Journal Article
T1 Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancer: a HuGE-GSEC review
A1 Varela Lema, María Leonor
A1 Taioli, Emanuela
A1 Ruano Raviña, Alberto
A1 Barros Dios, Juan Miguel
A1 Anantharaman, Devasena
A1 Benhamou, Simone
A1 Boccia, Stefania
A1 Bhisey, Rajani A.
A1 Cadoni, Gabriella
A1 Capoluongo, Ettore
A1 Chen, Chien-Jen
A1 Foulkes, William D.
A1 Goloni Bertollo, Eny Maria
A1 Hatagima, Ana
A1 Hayes, Richard B.
A1 Katoh, Takahiko
A1 Koifman, Sergio
A1 Lazarus, Phillip
A1 Manni, Johannes J.
A1 Mahimkar, Manoj
A1 Morita, Shunji
A1 Park, Jong
A1 Park, Kwang-Kyun
A1 Pavarino Bertelli, Erika Cristina
A1 Ribeiro, Enilze Maria de Souza Fonseca
A1 Roy, Bidyut
A1 Spitz, Margaret R.
A1 Strange, Richard C.
A1 Wei, Qingyi
A1 Ragin, Camille C.
K1 GSTM1
K1 CYP1A1
K1 Oral and pharyngeal cancer; Epidemiology; meta
K1 Pooled analysis
AB The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.
PB Nature Publishing Group
SN 1098-3600
YR 2008
FD 2008
LK http://hdl.handle.net/10347/13418
UL http://hdl.handle.net/10347/13418
LA eng
NO Varela-Lema, L., Taioli, E., Ruano-Ravina, A., Barros-Dios, J.M., Anantharaman, D., Benhamou, S., Boccia, S., Bhisey, R.A., Cadoni, G., Capoluongo, E., Chen, C.J., Foulkes, W., Goloni-Bertollo, E.M., Hatagima, A., Hayes, R.B., Katoh, T., Koifman, S., Lazarus, P., Manni, J.J., Mahimkar, M., Morita, S., Park, J., Park, K.K., Pavarino Bertelli, E.C., de Souza Fonseca Ribeiro, E.M., Roy, B., Spitz, M.R., Strange, R.C., Wei, Q., Ragin, C.C. (2008). Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. "Genetics in Medicine", 10(6), 369–384
DS Minerva
RD 25 abr 2026