RT Journal Article
T1 Cognition and brain network connectivity in timed up & go performance
A1 Varela-López, Benxamín
A1 Galdo Álvarez, Santiago
A1 Felpete López, Alba
A1 Habeck, Christian
A1 Stern, Yaakov
A1 Facal Mayo, David
K1 Gait
K1 Memory
K1 Executive functions
K1 Resting state connectivity
AB Gait performance depends on numerous aspects of brain functioning that are also relevant to key cognitive processes throughout the lifespan. The Timed Up and Go (TUG) test has been shown to be a reliable tool for assessing age-related mobility changes and risk of falls in older adults. This study aimed to predict TUG performance using motor-cognitive inter-network connectivity, cognitive performance and socio-demographics. 189 participants without cognitive impairment were included. Mobility was measured with the TUG through a wireless inertial sensor device. Functional connectivity between the somatomotor hand, cerebellar, and cognitive-related networks was assessed using pairwise correlations among 264 predefined regions assigned to large-scale functional networks. Connectivity between networks was summarized by averaging Fisher z-transformed values across all ROI pairs linking each network pair. Three linear regression models were constructed including the dependent variables TUG total time, turning time and turning peak-angular velocity (PAV) and the independent variables age, sex, years of education, memory and executive performance, and inter-network connectivity patterns. Somatomotor hand – ventral attentional and cerebellar – DMN inter-network connectivity were significant predictors of TUG total time. Memory performance, somatomotor hand – salience and –cingulo opercular inter-network connectivity were significant predictors of turning time. Age, years of education, somatomotor hand – dorsal attentional and cerebellar – cingulo opercular network activation were significant predictors of turning PAV. Findings indicate different contributions of attentional systems to gait performance in aging
PB Springer
YR 2025
FD 2025-11-24
LK https://hdl.handle.net/10347/44106
UL https://hdl.handle.net/10347/44106
LA eng
NO Varela-López, B., Galdo-Álvarez, S., Felpete, A., Habeck, C., Stern, Y., & Facal, D. (2025). Cognition and brain network connectivity in timed up & go performance. GeroScience, 10.1007/s11357-025-02016-7. Advance online publication. https://doi.org/10.1007/s11357-025-02016-7
NO This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11357-025-02016-7
NO Galician Government (GI-1807-USC- 2021-PG011: Ref. ED431C 2021/04)
DS Minerva
RD 4 may 2026